PHAR CH 17
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A colonization of pathogenic organisms that leads to tissure destruction.
sINGLE CELLED MICRO ORGANISMS
Plant like organisms that lack chlorophyll
Submicroscopic organisms that invaades living cells.
Organisms tha live on or inside another organisms.
Single celled microbe with animal characteristics.
- Single celed organisms
- Most abundant organisms on earth (and in our bodies)
oXYGEN NECCESSARY FOR NORMAL METABOLISM.
oxygen not recquired, and may even be toxic
Drugs that kill slow growth of bacteria.
A drug that inhibits the growth of an infectuous organism.
a drug tha kills the infectious organism.
SELECTION OF ANTIBIOTICS
- 1. lIVER/ KIDNEY FUNCTION
- 2. Age
- 3. Pregnancy
- 4. Resistance- Combination Drugs
The ability of na organism to withstand the effects of an organism.
- Due to:
- Frequent overuse (Common cold)
- Incomplete treatment
Resistamce Nosocomial Infections
Hospital acquired often resistant ot at least one drug.
Methicillin Resistant Staph aureus
ANTIBIOTICS ADVERSE REACTION
- Allergic- Mild- urticaria
- Severe Anaphylaxis
- indirect toxicity:
- New infection caused.
Uses: Short term treatment of serious infections.
- Narrow spectrum
Semi synthetic, derived from fungus like penicillin.
CEPHALOSPORINS 3 generations
- 1st- cephalexin 9Keflex)
- 2nd- cefaclor (Ceclor)
- 3rd- ceftiazxone (Rocephin)
SE's abdominal cramping anorexia
- iNDICATIONS sYPHLIS, RESPIRATORY AND INTESTINAL INFECTIONS.
- SE's: N/V. diarrhea, allergic reactions
- PenicillinG (Bycillin)
- amoxicillin (Amoxil)
- ampicillin (Principen)
- indications: Urinary tract infection, respiratory infections.
- SE's: CNS, headache, confusion.
- Vroad Spectrum
- SE'S: Yellowing of teeth (Children)
- Potentiation: with anti inflammatory drugs
- Antagonistic: wthh oral BC pills
- doxycycline (Vibramycin)
Members of the plant family. they contain no chlorophyl to sustain themselves.
Superficial- skin hair, mucous membranes
SYSTEMIC FUNGAL INFECTIONS
Fungal pneumonia is caused by Aspergillus
SYSTEMIC ANTIFUNGAL DRUGS
amphotericin B (Fungizone)
IV only highly toxic to:
- The auditory nerve (Ototoxicity)
- The kidneys (nephrotoxicity)
SYSTEMIC ANTIFUNGAL DRUGS
Better tolerated. Oral dosage form.
Treatment after exposure to prevent the development of disease.
- 6-12 months:
- 1. isoniazid (INH) alone or with
- 2. rifampin (Rifadin)
SE's: Liver toxicity, nausea/ vomitting
- Indications: AIDS pneumonia (pneumocytis carinii)
- Topical preparation for acne (Cleocin-T)
- Contraindications: Pregnancy
- Hepatic or renal failure.
- protozoal infections
- -trichomonas (STD)
- -giardia (travelers)
Intestinal Infections (h.pylori)
SE's: Abdominal Pain, metallic taste.
Submicroscopic infectious agent.
- Can only grow and multiply in liveing cells.
- Most are removed by our immune system.
- Some (Hepatitis) can remanin and cause long term illness.
Do NOT cue infections.
Given tp reduce tje severity and durations of symptoms.
Indications: Herpes simplex, H. zoster,
Side effects: Fatigue, headache.
Indications: Influenza viral infections
SE's: CNS-dizziness, nervousness, confusion.
One of the oldest groups of antibiotics.
Resistance has led to combination therapy.
Indications: UTI AIDS pneumonia.
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