Pharmacology Chapter 12

The general indication for clinical use of nonsteroidal antiasthma agents is:
A. short-term control of bronchospasm
B. long-term control of bronchospasm
C. control of severe asthma attack
D. prophylactic management of mild persisten asthma

Nonsteroidal antiasthma drugs are:
A. relievers
B. b2 antagonists
C. antiinfectives
D. controllers

The brand name for cromolyn sodium is:
A. Singulair
B. Intal
C. Tilade
D. Accolate

Cromolyn sodium is available in all of the following forms except:
A. neb
B. tablet
C. MDI
D. nasal spray

Which of the following are antileukotrienes?
I. Zafirlukast
II. Zileuton
III. Cromolyn Sodium
IV. Montelukast
V. Nedocromil Sodium
A. I, II, and III only
B. I, II, and IV only
C. III and V only
D. II, IV, and V only

Cromolyn sodium is effective in preventing bronchospasm by:
A. blocking cholinergic receptor sites
B. stimulating b2-adrenergic sites
C. inhibiting mast cell degranulation
D. enhancing mast cell degranulation

The most commonly reported side effect of cromolyn sodium is:
A. nasal congestion
B. diarrhea
C. pneumonia
D. headache

The usual dose of nebulized cromolyn sodium is:
A. 80 mg 3xday
B. 30 mg 3xday
C. 10 mg 4xday
D. 20 mb 4xday

Nedocromil Sodium is administered by:
A. tablet
B. dpi
C. neb
D. MDI

Tilade is effective as an intiinflammatory by inhibiting activation and activity of which of the following?
I. sensory neurons
II. mast cells
III. airway epithelial cells
IV. eosinophils
A. II only
B. I, II, and IV only
C. I and II only
D. I, II, III, and IV

It has been suggested that intal and tilade are effective as antiinflammatory agents by blocking transport of what ion into inflammatory celss?
A. chloride
B. potassium
C. sodium
D. bicarbonate

Leukotrienes exhibit which of the following effects?
I. incr mucus secretion
II. inhibition of normal ciliary action
III. incr airway edem
IV. bronchoconstriction
V. recruitment of other inflammatory cells into airways
A. I, II, and IV only
B. IV only
C. III, IV, V only
D. I, II, III, IV, and V

Zileuton interacts with which of the following respiratory care drugs?
I. theophylline
II. albuterol
III. warfarin
IV. ipratropium bromide
V. beclamethasone
A. I and III only
B. III and V only
C. II and IV only
D. I and V only

Zafirlukast is a :
A. corticosteroid
B. B adrenergic
C. leukotriene receptor stimulator
D. leukotriene receptor antagonist

The only antileukotriene agent currently approved for use in ped patients:
A. intal
B. singulair
C. accolate
D. tilade

What is clinical indication for use of leukotriene modifiers, such as montelukast, in asthma?
A. mast cell stabilizer
B. as a long-acting bronchodilator in step 3 asthma
C. alternative to or in combo with inhaled steroids
D. rescure bronchodilator in step 1 asthma

After a patient begins cromolyn sodium, how long may it take to show improvement in symptoms?
A. 2-4 weeks
B. 1-3 months
C. 24 hours
D. 4-6 days

Which of the following is considered a mast cell stabilizer?
A. cromolyn sodium
B. zileuton
C. zafirlukast
D. montelukast

Which of the following nonsteroidal antiasthma agents is formulated as an MDI?
A. nedocromil
B. zafirlukast
C. zileuton
D. montelukast

Which of the following is a monocolonal antibody used to reat asthma?
A. nedocromil
B. omalizumab
C. montelukast
D. zileuton

Advantages to the use of antileukotrienes include all of the following except:
A. effective in more than 90% of patients
B. additive effect w/ inhaled steroids
C. a formulation availabe for ped use
D. oral admin

Which drug is a lipid-soluble, intracellular receptor agonist that prevents inflammatory response?
A. singulair
B. flovent
C. xolair
D. zyflo