Pharmacology Chapter 12

The general indication for clinical use of nonsteroidal antiasthma agents is:
A. prophylactic management of mild persisten asthma
B. long-term control of bronchospasm
C. short-term control of bronchospasm
D. control of severe asthma attack

Nonsteroidal antiasthma drugs are:
A. antiinfectives
B. controllers
C. b2 antagonists
D. relievers

The brand name for cromolyn sodium is:
A. Accolate
B. Tilade
C. Singulair
D. Intal

Cromolyn sodium is available in all of the following forms except:
A. neb
B. nasal spray
C. tablet
D. MDI

Which of the following are antileukotrienes?
I. Zafirlukast
II. Zileuton
III. Cromolyn Sodium
IV. Montelukast
V. Nedocromil Sodium
A. I, II, and III only
B. III and V only
C. II, IV, and V only
D. I, II, and IV only

Cromolyn sodium is effective in preventing bronchospasm by:
A. stimulating b2-adrenergic sites
B. blocking cholinergic receptor sites
C. enhancing mast cell degranulation
D. inhibiting mast cell degranulation

The most commonly reported side effect of cromolyn sodium is:
A. headache
B. nasal congestion
C. diarrhea
D. pneumonia

The usual dose of nebulized cromolyn sodium is:
A. 10 mg 4xday
B. 30 mg 3xday
C. 20 mb 4xday
D. 80 mg 3xday

Nedocromil Sodium is administered by:
A. neb
B. MDI
C. tablet
D. dpi

Tilade is effective as an intiinflammatory by inhibiting activation and activity of which of the following?
I. sensory neurons
II. mast cells
III. airway epithelial cells
IV. eosinophils
A. II only
B. I, II, III, and IV
C. I and II only
D. I, II, and IV only

It has been suggested that intal and tilade are effective as antiinflammatory agents by blocking transport of what ion into inflammatory celss?
A. sodium
B. chloride
C. bicarbonate
D. potassium

Leukotrienes exhibit which of the following effects?
I. incr mucus secretion
II. inhibition of normal ciliary action
III. incr airway edem
IV. bronchoconstriction
V. recruitment of other inflammatory cells into airways
A. I, II, III, IV, and V
B. IV only
C. III, IV, V only
D. I, II, and IV only

Zileuton interacts with which of the following respiratory care drugs?
I. theophylline
II. albuterol
III. warfarin
IV. ipratropium bromide
V. beclamethasone
A. I and III only
B. II and IV only
C. III and V only
D. I and V only

Zafirlukast is a :
A. leukotriene receptor antagonist
B. B adrenergic
C. leukotriene receptor stimulator
D. corticosteroid

The only antileukotriene agent currently approved for use in ped patients:
A. tilade
B. singulair
C. intal
D. accolate

What is clinical indication for use of leukotriene modifiers, such as montelukast, in asthma?
A. alternative to or in combo with inhaled steroids
B. rescure bronchodilator in step 1 asthma
C. as a long-acting bronchodilator in step 3 asthma
D. mast cell stabilizer

After a patient begins cromolyn sodium, how long may it take to show improvement in symptoms?
A. 2-4 weeks
B. 24 hours
C. 4-6 days
D. 1-3 months

Which of the following is considered a mast cell stabilizer?
A. zileuton
B. cromolyn sodium
C. montelukast
D. zafirlukast

Which of the following nonsteroidal antiasthma agents is formulated as an MDI?
A. zafirlukast
B. montelukast
C. zileuton
D. nedocromil

Which of the following is a monocolonal antibody used to reat asthma?
A. montelukast
B. zileuton
C. nedocromil
D. omalizumab

Advantages to the use of antileukotrienes include all of the following except:
A. oral admin
B. a formulation availabe for ped use
C. additive effect w/ inhaled steroids
D. effective in more than 90% of patients

Which drug is a lipid-soluble, intracellular receptor agonist that prevents inflammatory response?
A. flovent
B. singulair
C. xolair
D. zyflo