N304 pharm final

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cbishop
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84141
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N304 pharm final
Updated:
2011-05-06 01:28:38
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N304 DM drugs pharm
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N304 DM drugs pharm
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  1. Names of rapid insulins
    Lispro, Humalog, Aspart, Novolog, Gluisine, Apidra
  2. Names of short acting insulin
    "regular"
  3. Names of intermediate acting insulin
    NPH, Lente
  4. Names of long acting insulin
    Detemir, Levemir
  5. Names of very long acting insulins
    Glargine, Lantus
  6. avg. peak for rapid acting insulin
    • ~1-3 hours
    • (Lispro and Humalog is 1-1.5 hours)
  7. Peak for regular insulin?
    2-4 hours
  8. Peak for Glargine/Lantus insulins?
    No peak
  9. Why would you have an increased need for insulin?
    • Body Growth
    • Hormonal changes (like pregnancy)
    • Increased food intake
    • stress-physical or emotional
    • Illness, even if they are not eating
  10. What would be reasons why you would need a decrease of insulin?
    • Exercise
    • Diseases (ex. end stage renal disease)
    • Decreased food intake
  11. Diabenase-chlorpropamide
    • (first generation)
    • Sulfonylureas
  12. Micronase; Diabeta-glyburide
    • (second generation)
    • Sulfonylureas
  13. Glucotrol- Glipizide
    • (second generation)
    • Sulfonylureas
  14. Glimepiride-Amaryl
    Sulfonylureas
  15. Glucophage (metformin)
    Biguanides
  16. Action of Sulfonylureas
    • Stimulate insulin production in the pancreas
    • Increase receptor sensitivity
    • ? Increase # of receptors
  17. Action of Biguanides
    Reduces glucose production by the liver and absorption in the intestine. It also enhances uptake and use of glucose by peripheral tissues.
  18. Acarbose (Precose)
    A-Glucosidase Inhibitors
  19. Miglitol (Glyset)
    A-Glucosidase Inhibitors
  20. Action of A-Glucosidase Inhibitors
    Competitive, reversible inhibitor of pancreatic alpha-amylast, which hydrolyzes complex CHOs to oligosaccharides. By inhibiting this enzyme, Acarbose delays digestion of starches.
  21. drugs ending in "-glinide"
    Nateglinide, Repaglinide
    Meglinitinides
  22. Action of Meglitinides
    Stimulate the release of insulin
  23. drugs ending in "-glitazone"
    ex: pioglitazone, rosiglitazone
    Thiazolindinediones--Glitazones
  24. Action of Thiazolidinediones--Glitazones
    improves bodys ability to use insulin. Reverse insulin resistance at cellular level by agonizing the receptors that regulate insulin-uptake. Also decrease hepatic glucose output.
  25. Pramlintide (Symlin)
    Noninsulin Polypeptide Analogues
  26. Action of Noninsulin Polypeptides Analogues
    Slows gastric emptying, suppresses release of glucagon, suppresses appetite because increases feeling of satiety.
  27. Gastric Inhibitory Peptide (GIP)
    Incretin
  28. Glucagon-like peptide (GLP-1)
    Incretin
  29. Exenatide (Byetta)
    Incretin Mimetic
  30. Actions of Incretins
    • Increase amount of insulin secreted
    • Decrease amount of glucagon secreted
    • Delay Gastric emptying
    • Increase feeling of satiety
  31. Sitagliptin (Januvia)
    Incretin enhancer
  32. Action of Glucagon
    Increases BS through glycogenolysis and gluconeogenesis

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