Renal Physiology

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  1. What percentage of cardiac output is renal blood flow?
    20% or 1200 mL/min
  2. Majority of renal blood flow goes where?
  3. Renal blood flow is regulated by what?
  4. What 6 factors increase blood flow?
    • Nitrous oxide
    • Dopamine
    • Prostaglandins
    • Histamines
    • Bradykinin
    • Serotonin
  5. What 7 factors decrease renal blood flow?
    • Thromboxanes
    • Endothelin
    • Norepinephrine
    • Epinephrine
    • Leukotrienes
    • ATI
    • ATII
    • Adenosine
  6. Normal GFR

    L/d ?
    • 120 mL/min
    • 180 L/d
  7. What is GFR dependent on?
    permeability of the capillary wall surface area available for filtration
  8. How much urine does the average person produce?
    1.5 L urine/day
  9. Where does most of the work happen? Before or after the glomerulus?
    Before - most gets reabsorbed
  10. What is normal RBF?
    70-180 mmHG of systolic blood pressure
  11. How does the tubuloglomerular feedback work?
    • Blood pressure is increased
    • Increases GFR
    • NaCl to macula densa (collecting system)
    • Afferent arterioles constrict
    • Decrease GFR

    (to decrease BP decrease NaCl)
  12. How does the myogenic theory work?
    Vasoactive factors from the arteriolar endothelium maintain a constant rate in response to BP changes
  13. What part of the tube stays constant despite blood pressure and glomerular filtration rates?
    PCT (proximal convoluted tubule)
  14. What osmotic state is found in the PCT (proximal convoluted tubule)?
  15. What is the main aspect of PCT (proximal convoluted tubule)?
    Na transport
  16. What osmotic state is found in the loop of henle?
  17. What is resorbed in the loop of henle?
    • Ca
    • Mg
  18. What is the osmotic state in the DCT (distal convoluted tubule)?
  19. What follows sodium?
  20. In which part of the tube is water impermeable?
    DCT (distal convoluted tubule)
  21. Where is most K reabsorbed?
    PCT (proximal convoluted tubule)
  22. Where is the primary site of ADH action?
    Collecting duct
  23. What are the 5 main homeostatic functions of the kidney?

    • Hormone regulation
    • BP regulation
    • Glucose homeostasis
    • Waste excretion
Card Set
Renal Physiology
Renal Physiology
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