Hemostasis

This is the stoppage of blood loss from a damaged vessel while continuing to maintain the blood in a fluid state within the vessels

What are the three types of Primary Hemostasis?

What are the two types of Secondary Hemostasis?

What are the three components of Hemostasis?

What initiates the platelet system?

What initiates the clotting system?

What happens upon damage to the epithelium?

What is the bridging protein between Glycoprotein Ib in platelets and collagen in the sub-epithelium?

What factor complexes to von Willebrand Factor?

What factor is synthesized by endothelial cells and megakaryocytes, and is found in plasma and platelet granules? It is stored in endothelial cells

When von Willebrand Factor complexes with GP Ib, it causes the release of ________ _______ from the platelet membrane. This activates the Prostaglandin Pathway, and Arachidonic Acid is converted to ___________ ______.

What are the four functions of Thromboxane A₂?

What molecule forms the bridge between two glycoprotein molecules in a platelet plug?

What lab test is used to assess the function of the Intrinsic Pathway?

What lab test is used to assess the function of the Extrinsic Pathway?

What factors are involved in the Intrinsic Pathway?

What factors are involved in the Extrinsic Pathway?

What factors are involved in the Common Pathway?

What molecule cleaves Fibrinogen into Fibrin?

What factor adds the covalent bonds between the Fibrin molecules, forming the permanent cross-links?

A deficiency of which Intrinsic Pathway factor does not bleed?

What is the mechanism for removing clots for wound healing? This system must be inactive unless needed, and must remain localized where the clot is present. These must not work in solution (plasma or blood), must be slow to be activated, and must be slow to break down the clot structure.

What is the most important co-enzyme complex in the Fibrinolytic System?

What enzyme breaks down the fibrin clot within the fibrinolytic system?

What are the three regulatory mechanisms of the Fibrinolytic System?

What Fibrinolytic System regulatory mechanism inhibits coagulation enzymes, mainly thrombin & factor Xa? It inhibits at the active site, and is potentiated by heparin-like molecules on the EC surface.

What Fibrinolytic System regulatory mechanism inactivates cofactors FV & FVIII? This requires complex formation.

What Fibrinolytic System regulatory mechanism inhibits factors VIIa and Xa? This inhibits the active site.

Which type of Hemostasis is the following symptoms associated with?

Bruising, Purpura, Gum Bleeding, Tooth Extract Bleeding, Rectal Bleeding, Menorrhagia, Hematuria, & Nose Bleeds

Which type of Hemostasis is the following symptoms associated with?

Hemathrosis (bleeding in joints), Muscle Bleeds, Hematoma, Retroperitoneal Bleeds, Circumcision Bleeding, & Umbilical Stump Bleeding

What are the Vitamin K-Dependent Procoagulant Proteins?

What are the Vitamin K-Dependent Anticoagulant Proteins?

Does the PT increase or decrease in Vitamin K Deficiencies?

What does Oral Anticoagulant Therapy decrease the risk for?

What is the International Normalized Ratio (INR) for the treatment of venous thrombosis?

All of the recommended International Normalized Ratio (INR) Ranges are targeted at 2.0-3.0, with the exception of the ratios for Mechanical Heart Valves & for Treatmetn of Lupus Anticoagulant. What is the ratio for these two?

Which laboratory test is used to monitor heparin therapy?

What acquired deficiencies does a PTT detect?

What acquired deficiencies does a PT detect?

What is heparin administered for?

What test is used to rule out thrombosis, as well as to confirm and monitor DIC?

If a patient presents with mucosal bleeding, what type of hemostasis is likely involved? What follow-up testing should be done?

If a patient presents with muscle or joint bleeding, what type of hemostasis is likely involved? What follow-up testing should be done?