Card Set Information
Psychobiology Exam Semester 2
Which part of the brain is invloved in Thinking, Planning, Emotion and Motor Control?
What is the Parietal Lobe responsible for?
Spatial Awareness, Sensations, Visual System.
Which part of the brain is known as the 'What Pathway'?
What is the temporal lobe responsible for?
Memory, Hearing, Facial Recognition
What is the Occipital Lobe also known as?
Which part of the brain is responsible for maintaining homeostasis?
The Hypothalamus is responsible for...?
Eating Behaviour, Emotions, Sleep Cycle
Which part of the brain is responsible for seasonal cycles?
Which hormone is secreted by the Pineal gland?
Which part of the brain contains dopamine receptors?
The Nucleus Accumbens is the _______ circuit?
What is the master gland in the brain?
Where are growth and stress hormones secreted from?
Which part of the brain acts as a relay station?
Which system regulates basic drives and emotion?
Which part of the Limbic system plays a part in reward?
Which part of the Limbic system plays a part in memory?
Schizophrenia is characterised by ______ episodes?
What are the positive symptoms of Schizophrenia?
Delusions, Hallucinations, Disorganised Thoughts
What are the negative symptoms of Schizophrenia?
Flat Affect, Alogia, Avolition, Anhedonia
Which type of symptom appears first?
Flat Affect means no ______?
Which symptom is characterised by uncommunicativeness?
What is the term for the inability to experience pleasure?
What is an alternative term for apathy?
There are over ___________ risk genes for Schizophrenia?
In the 1950's, drugs were discovered that blocked the action of dopamine at ______________?
Which illegal drug mimics the action of dopamine?
Amphetamines illustrate that dopamine is involved in ________?
Amphetamines prevent the reuptake of dopamine, therefore they are dopamine _________?
There is evidence that ________ drugs block dopamine?
The dopamine hypothesis says that Schizophrenia is related to an ___________ of dopamine neurones in the frontal cortex?
Postive symptoms of Schizophrenia are realted to excessive dopamine transmission in ___________?
Negative symptoms of Schizophrenia are related to a defecit in ________________?
Cortical dopamine transmission
Modern antipsychotic drugs are ______________?
Partial Agonists - they block partial receptor activity
The forst drugs in the 1950s that blocked the action of dopamine were _______?
The negative symptoms of Schizophrenia are associated with the __________ pathway?
The positive symptoms of Schizophrenia are associated with the _________ pathway?
Which dopamine receptor blocking drug was first found to eliminate positive symptoms of Schizophrenia?
Amphetamines and Cocaine produce the ________ symptoms of Schizophrenia?
There is an argument that antipsychotic drugs exert their therapeutic effects by ________ dopamine receptors?
The mesolimbic pathway leads from the Ventral Tegmental Area to __________?
Nucleus Accumbens and Amygdala
The mesolimbic pathway more likely to be associated with the positive symptoms of Schizophrenia because the Nucleus Accumbens is involved in ________?
What was the first treatment for depression in the 1950's?
Monoamine Oxidase Inhibitors
MAOI's inhibit the reuptake of _______ and _______?
Serotonin and Norepinephrine
What is the side effect associated with MAOI's?
The cheese effect
What was the next set of drugs which also inhibited the reuptake of serotonin and norepinephrine after MAOI's?
MAO Inhibitors and Tricyclic Antidepressants are ________?
The Monoamine Hypothesis says that depression is a result of insufficient activity of _________?
Depression is treated by _______ drugs?
Depression is caused by Monoamines ______?
What is the amino acid used to make Serotonin?
Experiments relating to tryptophan depletion suggest that the effect of antidepressants is dependent upon the availability of ________?
The 2-3 week timescale for antidepressants to begin working can be explained, as drugs which increase serotonin release may temporarily inhibit the activity of some serotonin neurones in the _______?
What is the difference in electrical charge between the inside and outside of a cell?
At resting potential, the charge is _____?
At resting potential, there is a higher ______ concentration outide the cell?
At resting potential, there is a higher concentration of ____ ions inside the cell?
Which mechanism restores the balance of ions across the mebrane following the generation of an action potential?
Sodium Potassium pump
During the depolarisation phase, there is more ________ inside than outside the cell?
Too much ________ leaves the cell to produce hyperpolarisation?
Which ion enters the cell during depolarisation?
Depression is associated with the neurotransmitter ________?
The activity of modern antipsychotic drugs is thought to be mediated within the ________?
At which phase do Potassium channels open to force out K+ ions?
At which phase does the electrical charge return to -70mv?
At what stage does the electrical charge overshoot past -70mv?
After the membrane overshoots its resting value, Sodium-potassium transporters remove ______ from inside and retrieve _____ from outisde the cell?
Na+ and K+
Between neurones, transmission is ________ in nature?
Between neurone communication is caused by the release of neurotransmitters, stimulated by _______?
What forces cause Na+ to rush into the cell during depolarisation?
Diffusion and Electrostatic Pressure
What are the two divisions of the Peripheral Nervous system?
Somatic and Autonomic
Which part of the PNS receives information from sensory organs and controls muscles?
Somatic nervous system
The sympathetic and parasympathetic are divisons of ________?
Autonomic nervous system
What is the name of the cell body of a neurone, which containes the nucleus?
What produces vesicles?
Which part of a cell is involved in the production of energy?
Dendrites receive messages from _______?
Axons are often covered in a ___________?
What is the name of supporting cells in the nervous system?
Which type of glia connect to many neurones in bundles within the CNS?
Which type of glia wraps around an axon in the PNS to form a segment?
What type of glia in the CNS surrounds many axons to form one segment around each?
The gaps in the myelin sheath which help the signal to regenerate are called _______?
Nodes of Ranvier
What are the two types of neurones?
Sensory and Motor
Schwann cells differ to Oligodendrocytes in function as they also aid in _________?
regeneration of damaged axons
What is a reduction (towards 0) of the mebrane potential?
An increase in the membrane potential is _______?
What is the term for the action potential appearing to jump from one Node of Ranvier to the next?
Neurotransmitters attach to the ________ of a receptor molecule?
In terminal buttons, molecules of nerotransmitter are found in ________?
By what process to neurotransmitters go across the synaptic gap?
Postsynaptic receptors open ________ to allow passage of ions?
Nerotransmitter dependent ion channels
By which two processes is the postsynaptic potential terminated?
Reuptake or Enzymatic deactivation
During reuptake, neurotransmitter is rapidly removed from the synaptic cleft by the _______?
At resting potential, the inside of the cell is more ______ charged?
The inside of the cell becomes positively charged at the _________?
Threshold of excitation following generation of an action potential
During hyperpolarisation, the membrane potential becomes more _______ than normal?
The opening of _______ occurs as a result of a change in membrane potential ?
Voltage dependent ion channels
Which VDI channel opens first as a result of a change in voltage?
An action potential travels along under the myelin sheath by ________?
At the hyperpolarisation phase, the membrane potential is ____?
A postsynaptic potential is a brief _______?
What is formed when groups of protein molecules in the vesicle attach to protein molecules in the membrane?
The release of vesicle contents into the synaptic cleft is called ________?
What opens as a result of the depolarisation when the action potential reaches terminal buttons?
Voltage Dependent Calcium Channels
What ions bind with the clusters of protein molecules in the membrane?
What process causes buds of the membrane to pinch off to stop the membrane becoming larger?
What process causes new vesicles to be formed?
What is the condition which means an individual cannot see certain parts within the visual field?
What part of the eye accounts for 80% of focussing power?
What controls the amount of light entering the eye?
What is the first optically active part of the visual system?
What are scotopic conditions?
Low light levels
What is the proportion of the two types of visual receptiors?
120 million rods, 5 million cones
Whcih part of the eye contains only cones?
Which part of the eye contains rods and cones?
Individuals born with only rods are called _______?
Are rods or cones better at night?
How does information travel from the eye to the brain?
the optic nerve
Which has a higher sensitivity - rods or cones?
What are the two types of ganglion cell output?
P cells and M Cells
Which ganglion cell output deals with colour/object information and is slow acting?
Which ganglion cell output is fast acting?
What are the two visual pathways?
Tectopulvinar and Geniculostriate
What is the bilateral structure which regulates the flow of information?
Lateral Geniculate Nucleus
How many layers does the LGN have?
Where is motor and colour information first separated?
What is the mid stage of visual processing?
Where are the larger receptors found?
What conditions arise as a result of damage to area V1?
Scotoma, Cortical Blindness
98% of visual information goes straight to area ____?
Which is the most cognitively dramatic area?
What is caused by lesions in area V4?
Cerebral Achromotopsia - inability to see colour
Which area is purely specialised in global motion?
What condition is the inability to perceive movement?
Where in the eye are receptors found?
Which receptor cell is more sensitive to light of low intensity?
Which receptor cell is responsible for daytime and colour vision?
What is the central region of the retina that mediates our most acute vision?
Which area of the brain is responsible for local motor detection?
In very dim light we use _____ vision?
When the photopigment of human rods is exposed to light, it breaks down into ______ and ______?
Opsin and Retinal
When rhodopsin is exposed to light, its colour changes to _______?
The inner two layers of neurones on the LGN are called _______?
The outer four layers of neurones in the LGN are called ________?
Information regarding colour and fine detail is transmitted by neurones in the ______ layer?
Information regarding the perception of form, movement and depth is transmitted by neurones in the ______ layer?
What is the primary visual cortex?
The photoreceptors connect to the ganglion cells via ______ cells?
What type of learning involves learning the connection between a behaviour and its consequences?
What says that responses followed by a pleasant outcome will increase in occurrence and responses followed by a negative outcome will decrease in occurrence?
Law of effect
A reqard or punisher is a conditioned _________?
The Skinner box was designed to look at the idea of _________?
What did Olds and Miller use to show what parts of the brain were involved in reward?
Stimulation of which area produces the most pleasure?
Medial Forebrain Bundle
The reward circuit lies within the ________?
Medial Forebrain Bundle
What are the three subdivisions of the MFB?
Nigrostriatal System, Mesolimbic System, Mesocortical System
Which system carries information from the VTA to the Nucleus Accumbens?
Drugs that block dopamine receptors in the Nucleus Accumbens also block _______?
A dopamine _______ interferes with reinforcement?
Opiates, Nicotine and Caffeine are dopamine _______?
Dopamine Agonist drugs release dopamine into the _______?
Animals will press levers to inject dopmaine ______ into the Nucleus Accumbens?
Lesions to the _______ disrupt behaviours learned through instrumental conditioning?
Systematic injections of dopamine agonists are ______?
Systematic injections of dopamine antagonists ______?
What is located in the Nucleus Accumbens, Basal Ganglia and Prefrontal Cortex?
Synaptic Change (Plasticity)
The major reward system of the brain is the ______?
Medial Forebrain Bundle
Physical dependence on a drug leads to _____ and _____?
Tolerance and Withdrawal
Tolerance is a decrease in ________?
What is the desensitisation of receptors which leads to tolerance?
Tolerance can occur as a result of decreased dendritic branching within the ______?
What is the principle active compound in opiates?
What is the second active compound in opiates?
Opiate receptors are present in the ______ and the _____?
Nucleus Accumbens and VTA
Injections of opiates cause release of ______ in the Nucleus Accumbens?
Cocaine and Amphetamines exert their addicting effects by altering the activity of the ___________?
Mesolimbic dopamine system
Cocaine increases the effectiveness of dopaminergic synapses by _______ the reuptake of dopamine?
Amphetamine blocks reuptake and ______ the release of dopamine?
Destruction of ______ can reduce addictive behaviour?