Cancer cells escape blood vessels
- One strategy:
- platelets attach to cancer cell in capillary forming a microthrombus.
This allows the cancer cell to push aside an endothelial cell and come into contact w/ the capillary basement membrane.
This provides a source of ECM attachment.
Microthrombus is dissolved by proteases that typically remove blood clots.
The cancer cell can proliferate -> mass of cells becomes large enough to break through the basement membrane