Verapamil (Isoptin, Calan)
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Calcium Channel Blocker
Clacium channel blocker that causes relaxation of vascular smooth muscle and slows conduction through the AV node.
Mechanism of Action
Slows conduction through the AV node, inhibits reentry during PSVT, decreases rate of ventricular response and decreases myocardial oxygen demand.
Onset of Action
- Onset: 5min
- Preak: 5-10min
- Duration: 10-60min
- Half-life: 2-8hrs
Used in PSVT refractory to adenosine
Heart Block, conduction system disturbance
Should not be used in pt receiving IV beta blockers, hypotension
Dizziness, Hypotension, Nausea, Vomiting
initial dose of 2.5-5mg if PSVT is not converted in 15-30min a 2nd dose of 5-10mg may be administered.
- 0-1 years: 0.2mg/kg (max 2.0mg) administered slowly.
- 1-15 years: 0.1-0.3mg/kg (max 5.0mg) administered slowly.
Routes of Administration
prefilled syringes and vials.
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