diffuse thickening of the glomerular basement membrane
mesangial matrix expansion
Post streptococcal glomerulonephritis
pathognomonic subepithelial deposits (D) with a semilunar, hump-shaped appearance. The humps sit on top of the glomerular basement membrane (GBM).
A neutrophil is attached to the denuded GBM, contributing to the glomerular inflammation. Neutrophil attraction requires the initial presence of subepithelial immune deposits so that complement chemoattractants have access to the systemic circulation.
Can be seen in IgA nephropathy and lupus nephritis
Segmental areas of increased mesangial matrix and cellulatiry
Dense electron dense deposits in mesangial regions