Immunology Short Course Questions

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Immunology Short Course Questions
2011-05-15 14:34:53

Coico and Sunshine
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  1. CDR
    • complementarity-determining regions
    • CDR1, 2, 3
    • aka hypervariable regions within Ig and TCR molecules
  2. 4 main differences between TCR and Ig
    • Valence & conformation: TCR is monovalent (2 chains), resembling the Fab fragment of an Ig; Ig is bivalent (4 chains)
    • Antigen recognition: TCR responds to peptide fragments associated with MHC; Ig recognizes linear and conformational epitopes of carbs/nucleotides/lipids/proteins
    • Secretion: TCR cannot be secreted
    • Somatic hypermutation: occurs only in B cells
  3. MHC
    • major histocompatibility complex
    • displays peptides for recognition by TCRs on T cells
    • Class 1: derived from cytoxolic proteins; recognized by CD8+ cells
    • Class 2: limited to professional APCs, macrophages, and B cells; recognized by CD4+ cells
  4. 4 requirements for immunogenicity
    • foreignness
    • high MW (<1kDa not immunogenic, >6kDa immunogenic)
    • chemical complexity
    • degradability and interaction w/ host MHC (antigen processing can reveal internal epitopes, unstable substrates won't bind to TCR/BCR)
    • amount administered
    • method of administration
  5. 4 Immunization administration methods and their characteristics
    • subcutaneous: strongest response b/c Langerhan cells are very potent APCs
    • IV: goes to spleen
    • oral-GI: local Ab response in GI lamina propria, but generally produces a systemic state of tolerance
    • intranasal: allergic response