Thrombosis

This is the formation of excessive amount of clot (fibrin and/or platelet derived) within the vessel lumen causing vessel occlusion.

A very high FVIII concentration can induce what?

What helps to maintain the balance in hemostasis (between coagulation and fibrinolysis)?

Which type of thrombosis (veinous or arterial) is coagulation based? WHich is platelet-derived?

How does Arterial Thromboemobolic Disease primarily manifest? What are the two clincial symptoms? What are the two treatments?

What color is a thrombus in an artery? In a vein?

Deep Vein Thrombosis in more common than _____ and _______ combined.

What is the leading cause of childbirth death in North America, as well as the most common preventable hospital death?

Coagulation generates VTE and then breakdown of fibrin clot forms ________. These become elevated in blood after the formation of a VTE, and are usually lower in patients without VTE. Therefore, we use this assay to rule out VTE.

This is a set of genetic abnormalities and/or acquired conditions which predisposes the individual to an increased risk of thromboembolic disease. This presents with mainly venous thrombosis, and usually manifests in young adults (20-50 years). The cause of the thrombotic presentation is usually spontaneous and an inciting event. This is a complex genetic disease -- there is no single cause. There is a standard treatment for all causes.

The two molecular causes of Thrombosis are a loss of function, caused by a deficit in ______________, and a gain in function, caused by an increase in ___________.

This is caused by an inability of patient's plasma to be inhibited by Activated Protein C (APC). There is a mutation of the APC cleavage site in what factor, and what is this known as?

The highest prevalence of abnormalities in patients with VTE is caused by what?

This mutation increases Prothrombin levels. The mechanism is longer surviving mRNA. This is a genetic abnormality.

In this syndrome, there is a heterogeneous family of auto-antibodies (lupus anticoagulant) against the PL-Protein Complex. The majority are asymptomatic, but about 30% of patients develop thrombosis. This can be transient or long term. Thrombosis and obstetrical complications can arise, including a.rterial, venous, and recurrent fetal loss

Most of the transient cases of Anti-Phospholipid Syndrome, or Lupus Anticoagulant, is due to what? What are the long-term cases due to?

What lab test is done for Anti-Phospholipid Syndrome, or Lupus Anticoagulant?

When is the optimum time to do a work-up on a Thrombophilia patient?

Heparin-induced thrombocytopenia is an immune-mediated activation of platelets. It results in ___________ due to platelet and coagulation activations.

How is Heparin-Induced Thrombocytopenia tested in the lab?