N304 Final

Home > Preview

The flashcards below were created by user cban09 on FreezingBlue Flashcards.


  1. Lipid Solubles?
    • ETOH
    • Gas Anesthetics
    • Barbiturates

    Not lipid soluble: ABX
  2. UEM
    EM
    PM
    • Ultra
    • Extensive Metabolizers
    • Poor
  3. How many half-lives to reach steady-state?
    5
  4. MEC
    MTC
    • Minimum Effective Concentration
    • Minimum Toxic
  5. Tachyphylaxis
    Quick drug tolerance
  6. What Vitamin interferes with Coumadin?
    Vitamin K found in green leafy vegetables
  7. Garlic IXs
    • insulin
    • hypoGs
    • Coumadin
    • antiHTNs
    • phenelzine
  8. Ginseng IXs
    • insulin
    • hypoGs
    • Coumadin
    • antiHTNs
    • phenelzine
    • CNS depressants
  9. IXs with CNS depressants
    • Ginseng
    • Kava
    • St Johns
    • Valerian
  10. St Johns IXs
    SSRIs
  11. IXs with anticoags
    • Garlic
    • Ginseng
    • Gingko
    • Ginger
    • Feverfew
  12. Dangerous CAMs
    • Chaparral: kidney, lymph
    • Comfrey: liver, lung, kidney, GI
    • Ephedra: CV
    • Kava: liver
    • Lobelia: depression, HTN
    • Yohimbe: HTN, tachy, dizzy, HA
  13. CAMs that inhibit clotting
    • chamomile
    • dandelion
    • dong quoi
    • horse chestnut
  14. CAMs that cause CNS depression
    • hope
    • kava
    • passion flower
    • valerian
  15. CAMs that decrease PLT aggregation
    • bilberry
    • don quoi
    • feverfew
    • fish oil
    • grape seed
    • Gs: garlic, ginseng, gingko
  16. Nitrates
    SE
    IX
    • HA, flushing, tachy, tolerance
    • CCB, Betas, ETOH, VIAGRA
  17. Beta Blockers
    FX
    SE
    IX
    • -chronotrope, -inotrope, after MI, no tolerance, taper off
    • bady, HF, hypoTN, metabolism, dizzy, lethargy, depression, dreams, impotence, wheeze
    • diuretics, antiHTNs, phenothiazines, anticholinergics, obscures hypoG sxs
  18. CCBs
    FX
    SE
    IX
    • arterial dilation, some -inotroope, depress nodes
    • flushing, HA, hypoTN, edema, [constipation, confu, drowsy, arrythmias, mood with Dilt and Verapamil]
    • betas, dig, grapefruit, STATINS
  19. Beat Blockers:
    • Atenolol: post MI
    • Metoprolol: LA
    • Propranolol: not selective, Asians may not metabolize
  20. CCBs:
    • -dipines
    • Diltiazem
    • Verapamil
  21. Bile Acid Sequestrants:
    • Questran
    • Colestid
    • Welchol
  22. HMG CoA Inhibitors:
    -statins
  23. Fibric Acid Derivitaves:
    • Gemfibrozil
    • Fenofibrate
  24. Niacin:
    Vitamin B3 in large doses
  25. Bile Acid Sequestrants
    SE
    IX
    • constipation, heartburn, N, gas (SE diminish)
    • lipid solubles (AEDK), dig, coumadin
  26. Bile Acid Sequestrants
    FX
    • increase bile-take cholesterol out of bloodstream
    • only work in gut (not as dangerous)
    • give with apple juice, FF
  27. HMG CoA Inhibitors
    FX
    lower cholesterol production in the liver
  28. Fibric Acid Derivitives
    FX
    decrease triglycerides
  29. Niacin
    FX
    increase lipase, breaks down cholesterol
  30. HMG CoA Inhibitors
    SE
    IX
    • mild GI, rash, HA, Rhabdomyolysis, increased liver panel, teratogenic
    • erythromycin, grapefruit, gemfibrozil, niacin (Rhabdo)
  31. Niacin
    SE
    flushing, pruritus, GI distress, hyperG, hyperuremia
  32. Thrombolytics:
    FX
    • convert plasminogen to plasmin, admin within 4-6hrs, no needles
    • Streptase: for MIs
    • Activase: for strokes
    • Tenecteplase
  33. Thrombolytics
    SE
    • allergy, NV, hypoTN
    • Streptase: itching
  34. Hemostatics:
    FX
    • Amicar
    • Desmopressin
    • Thrombin topical
    • stop bleeding, help with anemia, hemophilia (dental)
  35. Hemostatics
    SE
    nasal stuffiness, N, A
  36. Anti-coags
    SE
    • NV, HIT (5-10 days after, need plasmaphoresis)
    • Heparin: alopecia, osteoporosis (long term)
    • Coumadin: purple toe, necrosis
  37. Anti-coags
    Antidotes:
    • Coumadin: Vitamin K
    • Heparin: Protamine sulfate
  38. Normal PT:
    Desired with Coumadin:
    • 60-70 seconds
    • 90-175
  39. Normal aPTT:
    Desired with Heparin:
    • 30-45 seconds
    • 45-112
  40. Normal INR:
    Desired with Coumadin:
    • 0.5-1.5 seconds
    • 2 - 3.5
  41. Direct Thrombin Inhibitors:
    FX
    • -rudin
    • -roban
    • for HIT, coronary procedures, DVTs
  42. Antiplatelet Agents:
    • ASA
    • ADP Blockers: Plavix, Ticlid, Aggrenox
    • Glycoprotein Receptor Blockers: ReoPro, Integrilin, Aggrastat
  43. Plavix
    SE
    GI bleed, flu, HA, bruising, rash
  44. Ticlid
    SE
    NVD, dyspepsia, marrow toxic
  45. ReoPro
    SE
    bleeding, hypoTN, back/chest pain, thrombocytopenia
  46. Antidysrythmics:
    SE
    • Quinidine: D, cinchonism
    • Procainamide: V. dysrythmias, lupus syndrome
  47. MONA
    • Morphine
    • Oxygen
    • Nitro
    • ASA
  48. Andrenergic Agents:
    • Central: Clonodine, Methyldopa, Guanfacine
    • Peripheral: Serpasil
    • Alpha1 Blocker: Prazosin, Terazosin, Labetolol
    • Ganglionic Blocker: Inversine
  49. Andrenergic Agents
    SE
    drowsy, dry, HA, NC, rash, palps, depression
  50. ARBs:
    SE
    • -sartan
    • HA, dizzy, fatigue
  51. Vasodilators:
    SE
    • HA, NVD, dizzy, tachy, anxiety
    • Diazoxide
    • Hydralazine
    • Minoxidil
    • Nitroprusside
  52. Diazoxide
    SE
    • dysrythmias
    • hyperG
  53. Hydralazine
    SE
    edema, dyspnea, dyscrasias, hepatitis, congestion
  54. Minoxidil
    SE
    pericardial effusion, angina, breast tenderness, thrmobocytopenia
  55. Nitroprusside
    SE
    brady, decreased PLTs, cyanide toxicity
  56. ACE Inhibitors:
    FX
    • -pril
    • Decrease Na, prevent Angio I-Angio II, prevent bradykinin
  57. ACE
    SE
    IX
    • fatigue, HA, taste, cough, dyscrasias, mood, rash, angioedema (blacks)
    • NSAIDs, diuretics, antiHTNs
    • used often with CCBs and diuretics
  58. Cardiac Glycoside:
    SE
    Antidote
    • Digoxin
    • dysrythmias, NVAD, fatigue, confu, conv, depression, vision
    • digibind, K+
  59. + Inotropes
    • Digoxin
    • Primacor
    • Inocor
  60. Loop Diuretics
    FX
    • Lasix, Bumex, Demadex, Edecrin
    • Most potent, reduce Na and Cl, also vasodilate
  61. Loop Diuretics
    SE
    IX
    • orthostatic, lytes, tinnitus, glucose tolerance, dyscrasias, SJS, neuro/nephro toxic,
    • Increase uric acid (gout), liver panel, glucose
    • gentamycin, Dig, NSAIDs
  62. Thiazide Diuretics:
    FX
    • Hydrochlorothiazide, Chlorthalidone, Indapamide (sulfas)
    • Excrete Na, Cl, some K, also dilate arterioles, takes 3-4 weeks
  63. Thiazide diuretics
    SE
    IX
    • orthostatic, lytes, glucose tolerance, HA, rash, GI, libido
    • Dig, oral hypoGs (2 hours)
  64. K Sparing Diuretics:
    FX
    • Aldactone, Eplerenone, Dyrenium, Midamor
    • act in distal tubule
  65. K Sparing Diuretics
    SE
    IX
    • anemia, dizzy, sore, dry, menses, hirsutism, impotence
    • hyperK: N, fatigue, weak, brady, dysrythmias
  66. Osmotic Diuretics:
    FX
    • Mannitol, Colace, Ureaphil
    • in proximal tubule, used often for RF and ICP, lose many solutes
  67. Osmotic Diuretics
    SE
    Conv, thrombophlebitis, pulmonary congestion, HA, CP, tachy, fever, blurry
  68. Carbonic Anhydrates:
    FX
    • -amide
    • short term (3-4 days), for glaucoma, epilepsy, altitude sickness
  69. Carbonic Anhydrates
    SE
    • -amide
    • acidosis, drowsy, A, parasthesias, hematuria, urticaria, photo, melena
  70. Counter Regulatory to insulin:
    • GH
    • Glucagon
  71. Rapid Acting Insulins:
    Onset
    Peak
    Duration
    • Lispro, Humalog, Aspart, Nvolog
    • 5-20 minutes
    • 1-3 hours
    • 3-5 hours
  72. Short Acting Insulin:
    Onset
    Peak
    Duration
    • Regular
    • 30-60 minutes
    • 2-4 hours
    • 6-10 hours
  73. Intermediate Acting Insulins:
    Onset, Peak, Duration
    • NPH, Lente
    • 1-4 hours
    • 6-12 hours
    • 18-28 hours
  74. Long Acting Insulins:
    Onset, Peak, Duration
    • Lantus, Glargine
    • 1 hour
    • None
    • 24 hours
  75. What factors may decrease insulin absorption:
    • Smoking
    • Disease (CKD)
  76. Take more insulin with which drugs:
    • Steroids
    • Thyroids
    • Contraceptives
  77. Take LESS insulin with which drugs:
    • ETOH
    • Anabolics
    • MAOIs
    • Betas
    • Salycilates
    • theophyllines
  78. Sulfonylureas:
    FX
    • Diabenase, Glyburide, Glipizide, Amaryl
    • Stimulate pancreatic insulin production, increase receptors
  79. Sulfonylureas
    SE
    IX
    • hypoG, agranulo, hemolytic, thrombocytopenia, rash, photo, jaundice, NV, fullness
    • Many IX (ETOH and Diabenase)
  80. Biguanides:
    FX
    SE
    • Metformin
    • reduces intestinal absorption and production of glucose
    • NVDA, metallic taste, lactic acidosis! (weak, aches, dizzy, brady)
  81. A-Glucosidase Inhibitors:
    FX
    SE
    • Precose, Glyset
    • delays digestion
    • gas, abd pain, D, increased liver panel
  82. Meglitinides:
    FX
    SE
    • Nateglinide, Repaglinide
    • stimulate insulin secretionhypoG, joint pain, URI
  83. Glitazones:
    FX
    SE
    • -glitazone
    • improve use of insulin
    • infection, myalgias, HA, edema, cholesterol, hepatotoxic
  84. Polypeptide Analogs:
    FX
    SE
    • Symlin
    • increases satiety, slows gastric emptying
    • severe hypoG (3hrs after), NV, HA, joint pain, cough
    • DO not mix with insulin (site)
  85. Incretins:
    IX
    • Byetta
    • Januvia
    • cocoa, rosemary
  86. Byetta
    SE
    • NV, allergy, HA, dyspepsia, GERD, restless, pancreatitis, RF possible
    • From Hela monster
  87. Januvia
    SE
    HA, D, nasopharyngitis
  88. Glucagon
    SE
    IX
    • NV, hyperG, BP changes +/-
    • Increases Coumadin levels
    • Betas decrease Glucagon

Card Set Information

Author:
cban09
ID:
85803
Filename:
N304 Final
Updated:
2011-05-14 20:24:38
Tags:
Pharmacology Pharm Saarmann N304 Nursing
Folders:

Description:
All heart/BP drugs, diabetic drugs, CAM drugs
Show Answers:

Home > Flashcards > Print Preview