Smooth muscle relaxant acting on vascular, bronchial, uterine, and intestinal smooth muscle; dilation of arterioles and veins in the periphery; reduces preload and afterload; decreases the work load of the heart and, thereby, myocardial oxygen demand.
Adult: Tablets; 0.3-0.4 mg SL; may repeat in 3-5 minutes to maximum of 3 doses.
NTG spray : 0.4 mg under the tongue; 1-2 sprays.
NTG IV infusion: begin at 10 to 20 mcg/min; increase by 5-10 mcg/min every 5 minutes
until desired effect.
Pediatric: Not recommended.
Duration of action
Onset: 1-3 minutes.
Peak Effect: 5-10 minutes.
Duration: 20-30 minutes or if IV, 1-10 minutes after discontinuation of infusion.
Pregnancy safety: Category C. Hypotension more common in geriatric poulation. NTG decomposes if exposed to light or heat. Must be kept in airtight containers. Active ingredient may have a stinging effect when administered.