Immuno

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Author:
bshin
ID:
85859
Filename:
Immuno
Updated:
2011-05-22 19:34:34
Tags:
Immuno
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Description:
Immunosi
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  1. Cyclosporine
    • immunosuppressant
    • bind cyclophilin-->inhibit calcineurin--> inhibit IL-2 production--> block Tcell activation

    • USE- suppress organ rejection after transplant
    • -autoimmune disorders

    • SE- nephrotoxic! (prevent with mannitol diuresis)
    • -increase risk of viral infections and lymphoma
  2. Tacrolimus
    • immunosuppressant
    • bind FK-binding protein--> inhibit IL-2 secretion

    USE- suppress organ rejection after transplant

    • SE-Nephrotoxic! peripheral neuropathy, HTN
    • Pleural effusion, hyperglycemia!
  3. Sirolimus (rapamycin)
    • immunosuppressant
    • bind, block mTOR--> inhibit T cell proliferation in response to IL-2

    USE- immunosuppressant after kidney transplant in combo w/ cyclosporine + corticosteroids

    SE- hyperlipidemia, thrombocytopenia, leukopenia
  4. Daclizumab
    • immunosuppressant
    • -monoclonal antibody with high affinity of IL-2 receptor on activated T cells

    USE- acute rejection of kidney transplant
  5. Azathioprine
    • immunosuppressant
    • antimetabolite precursor of 6-mercaptopurine--> block metabolism/synthesis of nucleic acids
    • -toxic to proliferating lymphocytes

    USE- kidney transplant, autoimmune disorders (glomerulonephritis, autoimmune hemolytic anemia)

    • SE- bone marrow suppression.
    • -metabolized by xanthine oxidase (so accumulates with Allopurinol!!)
  6. Muromonab-CD3
    • Immunosuppressant
    • -monoclonal antibody to CD-3 (epsilon chain)
    • --> block cell interaction with CD-3 for TCR signal

    USE- immunosuppressant for kidney transplant

    SE- Cytokine release syndrome! hypersensitivity reaction
  7. Aldesleukin
    IL-2

    • USE- renal cell carcinoma
    • -metastatic melanoma
  8. Erythropoeitin
    • USE- anemia
    • (esp. in renal failure)
  9. Filgrastim
    granulocyte colony stimulating factor GM-CSF

    USE- bone marrow recovery ex. Neutropenics
  10. Sargramostim
    GM-CSF

    USE- bone marrow recovery
  11. INF-alpha
    USE- Hep B, Hep C, Kaposi's sarcoma, leukemia, malignant melanoma
  12. IFN-beta
    USE- Multiple sclerosis
  13. IFN-gamma
    USE- chronic granulomatous disease
  14. Oprelvekin
    IL-11

    USE- thrombocytopenia
  15. Thrombopoietin
    USE- thrombocytopenia
  16. Digoxin Immune Fab
    anti-Digoxin

    USE- antidote for digoxin intoxication
  17. Infliximab
    anti-TNF alpha

    USE- Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis
  18. Adalimumab
    anti-TNF alpha

    USE- Crohn's disease, rheumatoid arthritis, Psoriatic arthritis
  19. Abciximab
    anti-glycoprotien IIb/IIIa

    • USE- prevent cardia ischemia in unstable angina
    • and patients after PCI
  20. Trastuzumab (Herceptin)
    anti-erb-B2

    USE- HER-2 overexpressing breast cancer
  21. Rituximab
    anti-CD20

    USE- B-cell non Hodgkin's lymphoma

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