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bshin
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Cyclosporine
- immunosuppressant
- bind cyclophilin-->inhibit calcineurin--> inhibit IL-2 production--> block Tcell activation
- USE- suppress organ rejection after transplant
- -autoimmune disorders
- SE- nephrotoxic! (prevent with mannitol diuresis)
- -increase risk of viral infections and lymphoma
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Tacrolimus
- immunosuppressant
- bind FK-binding protein--> inhibit IL-2 secretion
USE- suppress organ rejection after transplant
- SE-Nephrotoxic! peripheral neuropathy, HTN
- Pleural effusion, hyperglycemia!
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Sirolimus (rapamycin)
- immunosuppressant
- bind, block mTOR--> inhibit T cell proliferation in response to IL-2
USE- immunosuppressant after kidney transplant in combo w/ cyclosporine + corticosteroids
SE- hyperlipidemia, thrombocytopenia, leukopenia
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Daclizumab
- immunosuppressant
- -monoclonal antibody with high affinity of IL-2 receptor on activated T cells
USE- acute rejection of kidney transplant
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Azathioprine
- immunosuppressant
- antimetabolite precursor of 6-mercaptopurine--> block metabolism/synthesis of nucleic acids
- -toxic to proliferating lymphocytes
USE- kidney transplant, autoimmune disorders (glomerulonephritis, autoimmune hemolytic anemia)
- SE- bone marrow suppression.
- -metabolized by xanthine oxidase (so accumulates with Allopurinol!!)
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Muromonab-CD3
- Immunosuppressant
- -monoclonal antibody to CD-3 (epsilon chain)
- --> block cell interaction with CD-3 for TCR signal
USE- immunosuppressant for kidney transplant
SE- Cytokine release syndrome! hypersensitivity reaction
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Aldesleukin
IL-2
- USE- renal cell carcinoma
- -metastatic melanoma
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Erythropoeitin
- USE- anemia
- (esp. in renal failure)
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Filgrastim
granulocyte colony stimulating factor GM-CSF
USE- bone marrow recovery ex. Neutropenics
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Sargramostim
GM-CSF
USE- bone marrow recovery
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INF-alpha
USE- Hep B, Hep C, Kaposi's sarcoma, leukemia, malignant melanoma
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IFN-beta
USE- Multiple sclerosis
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IFN-gamma
USE- chronic granulomatous disease
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Oprelvekin
IL-11
USE- thrombocytopenia
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Thrombopoietin
USE- thrombocytopenia
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Digoxin Immune Fab
anti-Digoxin
USE- antidote for digoxin intoxication
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Infliximab
anti-TNF alpha
USE- Crohn's disease, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis
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Adalimumab
anti-TNF alpha
USE- Crohn's disease, rheumatoid arthritis, Psoriatic arthritis
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Abciximab
anti-glycoprotien IIb/IIIa
- USE- prevent cardia ischemia in unstable angina
- and patients after PCI
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Trastuzumab (Herceptin)
anti-erb-B2
USE- HER-2 overexpressing breast cancer
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Rituximab
anti-CD20
USE- B-cell non Hodgkin's lymphoma
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