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Fibroadenoma
- Small, mobile, firm mass
- Most common mass in women under 25
- Benign
- Not a precursor to cancer
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Intraductal papilloma
- Small tumor that grows in lactiferous ducts
- Bloody nipple discharge
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Phyllodes tumor
- Large mass of CT and cysts
- Affects older women
- May become malignant
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Most important prognostic factor in breast cancer
Axillary lymph node mets
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Treatment if tumor has estrogen receptors
Tamoxifen
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Treatment if tumor has HER2/neu
Trastuzumab
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Ductal carcinoma in situ
Arises from ductal hyperplasia
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Invasive ductal carcinoma
- Most common breast cancer
- Firm, fibrous, hard mass, due to desmoplasia
- Cells are small, glandular, and duct-like
- Poor prognosis
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Invasive lobular carcinoma
- Orderly rows of cells
- Bilateral
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Medullary carcinoma
- Fleshy, soft to palpation
- Good prognosis
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Inflammatory carcinoma
Peau d'orange appearance of skin, due to invasion by the carcinoma of the dermal lymphatics
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Paget's disease
- Eczematous patches on nipples
- Large cells with clear halos in epidermis
- Suggest an underlying neoplasm
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Fibrocystic disease
- Most common cause of breast lumps
- Often bilateral (unlike all cancers, except lobular)
- No increased risk of carcinoma
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Acute mastitis
- Breast abscess during breast feeding
- Usually caused by S. aureus
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Fat necrosis
Result of trauma
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Galactocele
Obstruction of lactiferous ducts, associated with oral contraceptive use
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