shosh: breast pathology

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The flashcards below were created by user shosh114 on FreezingBlue Flashcards.

Fibroadenoma
- Small, mobile, firm mass
- Most common mass in women under 25
- Benign
- Not a precursor to cancer
Intraductal papilloma
- Small tumor that grows in lactiferous ducts
- Bloody nipple discharge
Phyllodes tumor
- Large mass of CT and cysts
- Affects older women
- May become malignant
Most important prognostic factor in breast cancer

Axillary lymph node mets
Treatment if tumor has estrogen receptors

Tamoxifen
Treatment if tumor has HER2/neu

Trastuzumab
Ductal carcinoma in situ

Arises from ductal hyperplasia
Invasive ductal carcinoma
- Most common breast cancer
- Firm, fibrous, hard mass, due to desmoplasia
- Cells are small, glandular, and duct-like
- Poor prognosis
Invasive lobular carcinoma
- Orderly rows of cells
- Bilateral
Medullary carcinoma
- Fleshy, soft to palpation
- Good prognosis
Inflammatory carcinoma

Peau d'orange appearance of skin, due to invasion by the carcinoma of the dermal lymphatics
Paget's disease
- Eczematous patches on nipples
- Large cells with clear halos in epidermis
- Suggest an underlying neoplasm
Fibrocystic disease
- Most common cause of breast lumps
- Often bilateral (unlike all cancers, except lobular)
- No increased risk of carcinoma
Acute mastitis
- Breast abscess during breast feeding
- Usually caused by S. aureus
Fat necrosis

Result of trauma
Galactocele

Obstruction of lactiferous ducts, associated with oral contraceptive use