RETEPLASE (RETAVASE)

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Author:
RLESLIE
ID:
86146
Filename:
RETEPLASE (RETAVASE)
Updated:
2011-05-16 16:40:14
Tags:
RETEPLASE RETAVASE
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Description:
RETEPLASE (RETAVASE)
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  1. Class
    Fibrinolytic
  2. Description
    Retaplase is a DNA recombinant human tissue-type plasminogen activator that acts as a catalyst in the breakdown of plasminogen to plasmin
  3. Mechanism of Action
    Increases plasmin by increasing the conversation of plasminogen to plasmin. Breaks down fibrin clots
  4. Onset of Action
    • Onset: <5 min
    • Peak: Varies
    • Duration: Varies
    • Half Life: 13-16 min




  5. Indications
    Acute Coronary Syndrome
  6. Contraindications
    • Active bleeding, suspected aortic dissection, Traumatic CPR, Severe persistent hypertension, recent head trauma, known intracranial tumor, history of stroke in 6 months, pregnancy.

    • Benefit must out way risk if the pt has had major surgery in past 2 months, B/P 180 systolic or 110 diastolic that is controlled by medications, active ulcer disease or blood in stool, history of stroke, tumor, brain surgery, head injury, bleeding disorder, liver dysfunction, kidney failure, cancer or illness with possible thoracic abdominal or intracranial abnormalities, prolonged CPR.

  7. Precautions
    • Anaphylaxis
    • Emergency resuscitation drugs and equipment available
    • Antidysrthythmics (amiodarone, lidocaine, diltiazem, b-blockers) available
  8. Side
    Effects
    Allergic reaction, anaphylaxis, bleeding, fever, nausea and vomiting
  9. Adult Dose

    10 units IV over 2 min. May repeat in 30 min

  10. Pedi-Dose
    Not indicated
  11. Max Dose

    20 units

  12. Routes of Administration
    IV/IO
  13. How Supplied
    Vials

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