Hematopoietic Neoplasms

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Lineage deals with _______ versus ________.

Lymphoid vs Myeloid
Survival (aggressiveness) deals with _________ versus __________.

Short (acute) vs long (chronic)
All hematologic neoplasms can be classified based on the combination of what three characteristics?
- Lineage
- Survival (Aggressiveness)
- Predominant Site of Involvement
The predominant site of involvement is ______________ versus __________.

Blood & Bone Marrow vs Tissue
What is the time span of acute neoplasms? Chronic?
- Weeks or a few months
- Years
Acute survival generally involves ___________ cells, such as ____________. Chronic survival is manifested by predominantly ____________ cells.
- Immature -- blasts or very early precursors
- Mature
What neoplasm is characterized by a predominant site in the blood and bone marrow?

Leukemia
What lymphoid neoplasm is characterized by a predominant site in the tissue? Myeloid? Plasma cells?
- Lymphoma
- Granulocytic (myeloid) Sarcoma
- Plasmacytoma or Myeloma (in marrow)
What are the four main Myeloproliferative Neoplasms (MPNs)?
- Chronic Myeloid Leukemia (CML)
- Polycythemia Vera
- Essential Thrombocytopenia
- Primary Myelofibrosis
What type of neoplasms (acute or chronic) are the Myeloproliferative Neoplasms (MPNs)?

Chronic
This is a heterogenous group of clonal stem cell disorders characterized by decreased cell numbers (cytopenias), abnormal cell appearance (dysplasia), impaired cell function, and a variable tendency to transform to acute leukemia. These are relatively common.

Myelodysplastic Syndromes
Chronic Myeloid Leukemia (CML) deals with what cell type?

Granulocytes
Polycythemia vera deals with what cell type?

Erythrocytes
Essential Thrombocythemia deals with what cell type?

Megakaryocytes/Platelets
Primary Myelofibrosis deals with what cell type?

Fibroblasts (fibrosis), driven by neoplastic megakaryocytes
How are Acute Leukemias characterized in terms of proliferation? Maturation and Differentiation? Cell counts? Cell Appearances?
- Proliferation: Increased
- M&D: Generally Lost
- Cell Counts: Generally Increased
- Cell Appearance: Immature
How are Myeloproliferative Neoplasms (MPNs) characterized in terms of proliferation? Maturation and Differentiation? Cell counts? Cell Appearances?
- Proliferation: Increased
- M&D: Preserved
- Cell Counts: Increased
- Cell Appearances: Generally Mature; Normal
How are Myelodysplastic Syndromes (MDS) characterized in terms of proliferation? Maturation and Differentiation? Cell counts? Cell Appearances?
- Proliferation: Impaired
- M&D: Preserved, but Impaired
- Cell Counts: Decreased
- Cell Appearances: Mature but Dysplastic

Author

julieaburch

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Card Set

Hematopoietic Neoplasms

Description

Hematopoietic Neoplasms

Updated

2011-05-16T22:27:44Z

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