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Hematopoietic Neoplasms

  1. Lineage deals with _______ versus ________.
    Lymphoid vs Myeloid
  2. Survival (aggressiveness) deals with _________ versus __________.
    Short (acute) vs long (chronic)
  3. All hematologic neoplasms can be classified based on the combination of what three characteristics?
    • Lineage
    • Survival (Aggressiveness)
    • Predominant Site of Involvement
  4. The predominant site of involvement is ______________ versus __________.
    Blood & Bone Marrow vs Tissue
  5. What is the time span of acute neoplasms? Chronic?
    • Weeks or a few months
    • Years
  6. Acute survival generally involves ___________ cells, such as ____________. Chronic survival is manifested by predominantly ____________ cells.
    • Immature -- blasts or very early precursors
    • Mature
  7. What neoplasm is characterized by a predominant site in the blood and bone marrow?
    Leukemia
  8. What lymphoid neoplasm is characterized by a predominant site in the tissue? Myeloid? Plasma cells?
    • Lymphoma
    • Granulocytic (myeloid) Sarcoma
    • Plasmacytoma or Myeloma (in marrow)
  9. What are the four main Myeloproliferative Neoplasms (MPNs)?
    • Chronic Myeloid Leukemia (CML)
    • Polycythemia Vera
    • Essential Thrombocytopenia
    • Primary Myelofibrosis
  10. What type of neoplasms (acute or chronic) are the Myeloproliferative Neoplasms (MPNs)?
    Chronic
  11. This is a heterogenous group of clonal stem cell disorders characterized by decreased cell numbers (cytopenias), abnormal cell appearance (dysplasia), impaired cell function, and a variable tendency to transform to acute leukemia. These are relatively common.
    Myelodysplastic Syndromes
  12. Chronic Myeloid Leukemia (CML) deals with what cell type?
    Granulocytes
  13. Polycythemia vera deals with what cell type?
    Erythrocytes
  14. Essential Thrombocythemia deals with what cell type?
    Megakaryocytes/Platelets
  15. Primary Myelofibrosis deals with what cell type?
    Fibroblasts (fibrosis), driven by neoplastic megakaryocytes
  16. How are Acute Leukemias characterized in terms of proliferation? Maturation and Differentiation? Cell counts? Cell Appearances?
    • Proliferation: Increased
    • M&D: Generally Lost
    • Cell Counts: Generally Increased
    • Cell Appearance: Immature
  17. How are Myeloproliferative Neoplasms (MPNs) characterized in terms of proliferation? Maturation and Differentiation? Cell counts? Cell Appearances?
    • Proliferation: Increased
    • M&D: Preserved
    • Cell Counts: Increased
    • Cell Appearances: Generally Mature; Normal
  18. How are Myelodysplastic Syndromes (MDS) characterized in terms of proliferation? Maturation and Differentiation? Cell counts? Cell Appearances?
    • Proliferation: Impaired
    • M&D: Preserved, but Impaired
    • Cell Counts: Decreased
    • Cell Appearances: Mature but Dysplastic
Author
julieaburch
ID
86175
Card Set
Hematopoietic Neoplasms
Description
Hematopoietic Neoplasms
Updated

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