Hodgkin Lymphomas

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  1. The presence of what distinctive cell characterizes the heterogenous group of diseases known as Hodgkin Lymphomas?
    Reed-Sternberg Cell
  2. Identify the abnormal cell seen in the center of the picture below:
    Image Upload
    Reed-Sternberg Cell
  3. This type of lymphoma tends to show an orderly, contiguous pattern of spread: from one lymph node to the next lymph node down the chain, then the next, etc. This type tends to involve central or axial lymph nodes most often; peripheral lymph node involvement is much less common. Mesenteric lymph nodes and Waldeyer's ring are seldom involved, and these tend to be primarily lymph node diseases.
    Hodgkin Lymphomas
  4. This type of lymphomas tend to be widely disseminated diseases at diagnosis; they are usually present elsewhere. They often involve peripheral lymph nodes. Mesenteric nodes and Waldeyer's ring are often involved, and these tend to be primarily lymph node diseases.
    Non-Hodgkin Lymphomas
  5. Which are more common, Hodgkin Lymphomas or Non-Hodgkin Lymphomas?
    Non-Hodgkin Lymphomas
  6. There is a bimodal age distribution of Hodgkin Lymphomas in the US. When is the first peak? When is the second?
    • 20s
    • 60+
  7. Are Hodgkin Lymphomas more common in males or females?
  8. What infection is believed to be involved in about half of the cases of Hodgkin Lymphoma?
  9. Hodgkin Lymphomas are believed to be derived from what cell type?
  10. What are the two main classifications for Hodgkin Lymphomas per the WHO?
    • Nodular Lymphocyte Predominant HL
    • Classical HL
  11. What are the four subtypes of Classical Hodgkin Lymphoma per the WHO?
    • Nodular Sclerosis HL
    • Mixed Cellularity HL
    • Lymphocyte-rich classical HL
    • Lymphocyte-depleted classical HL
  12. This subtype of Hodgkin Lymphoma has a B-cell phenotype, which differs from the phenotype of all other variants of HL. It is a relatively uncommon variant, comprising only about 5% of all HL. There is a significantly higher incidence in males, and it typically occurs at a relatively young age. This type is characteristically localized (low stage) at presentation (stage I or II), and cervical, axillary, and inguinal lymph nodes are often involved.
    It has an indolent course, with long survival. There may be a tendency for late relapse. And this may transform to large cell Non-Hodgkin Lymphoma.
    Nodular Lymphocyte Predominant HL
  13. What is by far the most common subtype of HL?
    Nodular Sclerosis Classical HL
  14. This subtype of Hodgkin Lymphoma has an equal incidence in male and female populations. It is predominantly in young people (peak ~28 years), and is rare in older populations. This type is usually localized, and is most often stage II. Cervical, supraclavicular, and mediastinal involvement is common. This has a relatively indolent course.
    Nodular Sclerosis Classical HL
  15. What tends to be the staging of Nodular Sclerosis Classical HL? What lymph nodes are typically involved?
    • Stage II
    • Cervical, Supraclavicular, and Mediastinal
  16. What tends to be the staging of Nodular Lymphocyte Predominant HL? What lymph nodes are typically involved?
    • Stage I or II
    • Cervical, Axillary, or Inguinal
  17. What is the second my common subtype of Hodgkin Lymphoma?
    Mixed Cellularity Classical HL
  18. This subtype of Hodgkin Lymphoma tends to occur in the older population, and has a higher incidence in males than females. This is more often diagnosed at an advanced stage (III-IV), with an intra-abdominal disease more common (mediastinal disease uncommon). Clinically, this is a more aggressive HL. This tends to have more frequent malignant cells.
    Mixed Cellularity Classical HL
  19. What is the only subtype of Hodgkin Lymphoma that is more common in females than males (or equal incidence acutally)?
    Nodular Sclerosis Classical HL
  20. This subtype of Hodgkin Lymphoma is uncommon, and has a predominance of lympocytes and other benign cells. It has a higher incidence in males, and a slightly older population (median age = 50). This is usually localized (stage I or II), and has an indolent course.
    Lymphocyte-rich Classical HL
  21. This subtype of Hodgkin Lymphoma is uncommon, and typically affects older patients. The incidence is higher in males. This type is typically diagnosed at an advanced stage (stage III-IV), and has an aggressive course.
    Lymphocyte-depleted Classical HL
  22. This tends to be the most aggressive variant of Hodgkin Lymphoma -- often disseminated at diagnosis, with a more aggressive course with shorter survival.
    Lymphocyte-depleted Classical HL
  23. What is the Ann Arbor Staging System for Hodgkin Lymphoma?
    • Stage I: single lymph node or group
    • Stage II: more than one group, but same side of diaphragm
    • Stage III: disease both sides of diaphragm
    • Stage IV: extranodal (liver, bone marrow, or disseminated extranodal)
  24. What symptoms are linked to the Ann Arbor Staging System for Hodgkin Lymphoma?
    • Unexplained Fever (greater than 38 C)
    • Drenching Night Sweats
    • Unexplained Weight Loss ( more than 10 lbs)
  25. The presence of systemic symptoms in Hodgkin Lymphoma has a significant adverse prognostic indication. In relation to this, what do the suffixes "A" and "B" mean in the Ann Arbor Staging System?
    • A: systemic symptoms absent
    • B: systemic symptoms present
  26. What two things are associated with a worse prognosis?
    • Older Age
    • Bulky Disease
  27. What is the primary treatment for Hodgkin Lymphoma?
    Combination Chemotherapy
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Hodgkin Lymphomas
2011-05-17 00:14:55
Hodgkin Lymphomas

Hodgkin Lymphomas
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