This subtype of Hodgkin Lymphoma has a B-cell phenotype, which differs from the phenotype of all other variants of HL. It is a relatively uncommon variant, comprising only about 5% of all HL. There is a significantly higher incidence in males, and it typically occurs at a relatively young age. This type is characteristically localized (low stage) at presentation (stage I or II), and cervical, axillary, and inguinal lymph nodes are often involved.
It has an indolent course, with long survival. There may be a tendency for late relapse. And this may transform to large cell Non-Hodgkin Lymphoma.
Nodular Lymphocyte Predominant HL