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Lymphomas

The flashcards below were created by user bigfootedbertha on FreezingBlue Flashcards.

  1. B cell lymphomas are more common in what population?
    Males, older ages
  2. CD (cluster designation)20
    Small B cell
  3. Most common leukemia
    CLL
  4. Hypogammaglobulinemia
    CLL
  5. What age does CLL affect?
    >40
  6. Most arise in post germinal center memory B cells
    Marginal zone lymphoma
  7. m/c type of extranodal MZL
    Gastric maltoma
  8. may arise from helicobacter pylori
    Gastric maltoma
  9. Lymphoma seen in the breast, eye and skin
    Gastric maltoma
  10. What autoimmune diseases are associated with extranodal MZL/MALToma?
    Hashimotos, Sjogrens
  11. Lymphoma where cells may have villous projections, an indolent course, and found in older females
    Splenic marginal zone lymphoma
  12. Associated w/ Deletion in chromosome 7q21
    Splenic marginal zone lymphoma
  13. Lymphoma with neutrophil infiltration, marginal zone pattern, and monocytoid B cell component
    Nodal marginal zone lymphoma
  14. What genetic mutations are involved with follicular cell lymphoma?
    • t(14;18) translocation
    • bcl-2 gene
    • Addition of other genetic problems inactivating TP53 deleting P38/MAPK (antiapoptotic)
    • Activation of C-MYC
  15. What is a low grade follicular lymphoma?
    follicular small cell
  16. What is a higher grade follicular cell lymphoma?
    Diffuse large cell
  17. What population is affected by mantle cell lymphoma typically?
    middle aged and elderly males
  18. Aggressive small cell lymphoma with poor response to chemotherapy and extranodal involvement
    Mantle cell lymphoma
  19. Mutation involved with mantle cell lymphoma
    • Cyclin D , overexpression from t(11;14)
    • Overcomes suppressor effects of retinoblastoma and p27 protein
  20. What is the survival rate for aggressive mantle cell lymphoma?
    3-4 years
  21. Rapidly growing, sxmatic, lymphoma with a mass at a single site (either nodal or extranodal)
    Large B cell lymphoma
  22. Cleaved and non-cleaved large cells, Diffuse counterpart of nodular follicular lymphoma, More aggressive
    LBCL-centroblastic
  23. Large vesicular nucleus, prominent nucleolus, thick nuclear membrane, nuclear huff
    LBCL-immunoblastic
  24. What diseases is LBCL-immunoblastic associated with?
    Hashimotos, Sjogrens, SLE
  25. Big bubbly nucleus
    Large B cell immunoblastic
  26. Reactive T cell population
    LBCL-Tcell/histiocyte rich
  27. Diffuse growth pattern with fine interstitial fibrosis
    LBCL-Tcell/histiocyte rich
  28. Large bizarre, tumor cells with vascular involvement
    LBCL-anaplastic
  29. Superior vena cava syndrome-->enlarged neck veins, engorgement of the head
    Primary mediastinal thymic LBCL
  30. Locally invasive, multilobulated cells
    Primary mediastinal LBCL
  31. Primary CNS lymphoma is associated with what viruses
    HIV primarily, also EBV
  32. Primary CNS lymphoma is associated with what dz and virus?
    HIV primarily, also EBV
  33. HIV associated lymphoma caused by HHV-8
    Primary effusion lymphoma
  34. Homogeneous medium sized cells, rounded nuclei, multiple nucleoli , basophilic cytoplasm
    Burkitt Lymphoma
  35. Cytoplasmic lipid vacuoles with multiple large macrophages
    Burkitt lymphoma
  36. Starry sky pattern
    Burkitt lymphoma
  37. Rapid cell turnover, proliferation, and apoptosis
    Burkitt lymphoma
  38. What type of Burkitt lymphoma involves jaw and facial bones, where EBV is 100%?
    Endemic
  39. What type of Burkitt lymphoma involves abdominopelvic region, terminal ileum, cecum, and ovaries?
    Non-endemic
  40. What type of Burkitt lymphoma is systemic, extranodal, not in CNS, associated with EBV?
    Immunodeficiency
  41. Are Burkitt lymphomas passive or aggressive?
    All are aggressive
  42. How do peripheral T cell lymphomas compare to B cell lymphomas?
    They are less common than B cell lymphomas, some have a worse prognosis, some have a better prognosis
  43. Psoriasis type skin lesions
    Adult T cell lymphoma/leukemia
  44. What population is most commonly affected by adult T-cell lymphoma/leukemia?
    More common in Japan (rare in US)
  45. Aggressive lymphoma with hypercalcemia and lytic bone lesions due to increased osteoclastic activity
    Adult T cell lymphoma/leukemia
  46. Associated with human retrovirus HTLV1
    Adult T cell lymphoma/leukemia
  47. Anaplastic large cell lymphoma is more common in what population?
    Young adults
  48. cell with large eccentrice nuclei with prominent nucleoli
    Anaplastic large cell lymphoma
  49. W
  50. ALK1 antigen***
    Anaplastic large cell lymphoma
  51. Aggressive lymphoma with genearlized systemic sx and eosinophils
    Angioimmunoblastic T-cell lymphoma
  52. Presents with advanced disease, prominent vascularity
    Angioimmunoblastic T-cell lymphoma
  53. Pautrier's microabscesses
    Mycosis fungoides
  54. Cells with cerebriform nuclei (convolusion and grooves, looking like the brain)
    Mycosis fungoides
  55. Papillary dermal fibrosis
    mycosis fungoides
  56. A lymphoma that arises in the skin, looks like a fungal infection, with an indolent but progressive course
    Mycosis fungoides
  57. Mycosis fungoides with generalized adenopathy and cerebriform cells in the circulation
    Sezary syndrome
  58. Mycosis fungoides with peripheral involvement
    Sezary syndrome
  59. Lymphoma with trisomy of chromosome 8
    Hepatosplenic T-cell lymphoma
  60. young black males
    Hepatosplenic T-cell lymphoma
  61. Lymphoma with monotonous small to medium sized cells and an aggressive course
    Hepatosplenic T-cell lymphoma
  62. Sinusoidal infiltration of liver, spleen, and marrow
    Hepatosplenic T-cell lymphoma
  63. Reed-Sternberg cells
    Hodgkins Disease
  64. Lymphocyte predominance, mixed cellularity, lymphocyte depletion, nodular sclerosis
    Hodgkin Disease
  65. Popcorn cells
    HD lymphocyte predominance
  66. Prognosis of HD-lymphocyte predominant
    excellent
  67. HD with large number of lymphocytes mixed with histocytes
    Lymphocyte predominance
  68. Heterogenous cellular infiltrate presenting more often as disseminated disease
    HD-mixed cellularity
  69. Reed Sternberg cells plentiful
    HD-mixed cellularity
  70. What population tends to be affected by HD-mixed cellularity?
    Pts over 50, M>F
  71. What is the least common form of HD?
    HD-lymphocyte depletion
  72. Disseminated disease, PAUCITY
    OF LYMPHOCYTES,ABUNDANCE OF R-S CELLS
    HD-lymphocyte depletion
  73. M/C form of Hodgkin's Disease
    Nodular sclerosis
  74. Hyperlobate nuclei, multiple necleoli, surrounding by clear spaces
    Lacunar cells, a R-S variant associated with HD-nodular sclerosis
  75. COLLAGEN BANDS DIVIDE LYMPHOID TISSUE INTO NODULES
    HD-Nodular sclerosis
  76. INVOLVES LOWER CERVICAL, SUPRACLAVICULAR AND MEDIASTINAL LN
    HD-Nodular sclerosis
  77. What population is most commonly affected by HD-nodular sclerosis?
    F>M, adolescents or young adults
  78. What is the most important prognostic indicator of HD?
    clinical stage, because it spreads from LN to LN
  79. Hodgkins lymphoma stage one
    Single node region or single extralymphatic organ or site
  80. Hodgkins lymphoma stage two
    two or more nodes on the same side of the diaphragm or localized involvement of an extralymphatic organ or site
  81. Hodgkins lymphoma stage three
    Involvement of LN regions on both sides of the diaphragm or localized involvement of an extralymphatic organ or spleen or both
  82. Hodgkins lymphoma stage four
    Diffuse or disseminated involvement of one or more extralymphatic organs with or without associated LN involvement
Author
bigfootedbertha
ID
86334
Card Set
Lymphomas
Description
for my upcoming pathology exam
Updated
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