Pharm

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Author:
macco3
ID:
86403
Filename:
Pharm
Updated:
2011-05-19 16:22:11
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  1. Heparin Dosage
    5000 Units followed by 20,000-40,000 units/24 hours
  2. Septra Dosage for PJP
    20mg/kg TMP/100mg/kg SMX in 3-4 divided doses/day
  3. Zidovudine Dosage
    200mg TID or 300mg BID
  4. Warfarin dosage
    2-10mg po qday
  5. HAART
    • 2NRTI+PI
    • 2NRTI+1NNRTI (protease sparing therapy)
  6. Zidovudine
    • NRTI
    • Adverse: bone marrow depression (give epoetin), nausea, severe HA, insomnia, myalgia
  7. Didanosine
    • NRTI
    • Adverse: painful peripheral neuropathy, GI upset, wt gain
    • FDA warning: acute pancreatitis
    • do NOT mix w/juices, carbonated drinks
    • take w/ empty stomach
    • DDI: ketoconazole
  8. Lamivudine
    • NRTI
    • also used to tx chronic Hep B
    • used with zidovudine. increases zidovudine effect
    • Adverse: GI, neutropenia, peripheral neuropathy
  9. Indinavir
    • PI
    • good oral bioavailability, resistance develops slowly
    • mild elevation indirect bilirubin (liver fxn test)
    • kidney stones (rec 48oz H20/day)
    • best on empty stomach, light carb meal OK
    • long term toxicity: hyperglycemia, DM, hyperlipidemia
    • lipodystrophy--chubby in waist, skinny arms/legs
    • DDI: midazolam, triazolam
  10. Efavirenz
    • NNRTI
    • Good CNS penetration
    • Adverse: skin rash, Stevens Johnson, GI CNS (dizziness, abnormal dreams)
    • avoid high fat meals
    • contraindicated in pregnancy
    • DDI: midazolam, triazolam, warfarin
  11. Enfuvirtide
    • injectable SQ, rotate inj sites
    • Adverse: local injection site rxn, pain, induration, erhythemia
    • increase risk of pna
    • roll vial. must refridgerate
  12. Raltegravir
    • for multilpe resistant HIV
    • Adverse: GI, MI, renal failure
    • rhabdomyolysis (m/s destruction)
    • has additive drug interxn with statins
  13. What OI is Septra/Bactrim used for?
    PCP/PJP
  14. TMP/SMX
    • tx: PCP/PJP
    • Adverse: GI, skin rash, erythema multiforme, Stevens Johnson, blood dyscrasias
  15. Pentamindine Isethionate
    • tx of PCP, African Trypanosomiasis 'sleeping sickness'
    • can be used prophylactically-given via inhalation
    • Adverse: hypotension, blood dyscrasis, hypoglycemia, hyperglycemia, pancreatitis
  16. Heparin Test
    aPTT
  17. Heparin indications
    pre-surgery, cardiovascular, orthopedic (hip, knee), abd, thoracic
  18. Heparin FDA warning
    HIT-heparin induced thrombocytopenia
  19. Heparin precautions
    • blood dyscrasis, peptic ulcer, any bleeding, undergoing brain/spinal surgery
    • avoid giving meds IM
  20. Heparin DDI
    ASA, any anticoagulant
  21. Enoxapin FDA warning
    should not be used pt in epidural, spinal anesthesia, spinal tap.
  22. Enoxapin Test--indications
    • Antifactor 10A
    • done for multi-organ dysfxn
    • obese
    • liver
    • pregancy
    • pediatrics
  23. Warfarin test
    PT/INR
  24. Warfarin clinical uses
    • long term control
    • chronic occlusive disease
    • previous heart attacks
  25. Warfarin
    Adverse effects
    • Bleeding
    • fever
    • HA
    • GI
  26. Warfarin antidote
    Vit K
  27. Warfarin Precautions
    • Pregnancy X category
    • if severe bleeding, give blood/plasma
  28. Warfarin DDI
    • corticosteroids
    • ASA
    • gingko
    • megadoses of vit E
    • EtOH
    • causes subdural hematoma
  29. ASA
    • prevent MI
    • post MI
    • TIA-prevent stroke
  30. Dipyrimadole
    • coronary vasodilator w/ antiplatelet activity
    • adverse effects: GI distress, HA, dizziness, hypotension
  31. Clopidogrel
    • prevent MI, stroke/vascular death, acute coronary syndrome
    • Adverse: HA, URTI, chest pain, flu-like sxs
    • DDI: ASA, atorvastatin, ginko, giner, garlic, warfarin, PPI
    • Precaution: lactation, active bleeding
  32. Cyclophosphamide
    • n/v
    • thrombocytopenia
    • alopecia
    • immunosuppression
    • hemorrhagic cystitis--drink fluids
  33. Cisplatin
    • Severe N/v. Pre-treat with ondansetron
    • give 1/2 hr before, then 4, 8 after, then prn
    • kidney damage-flush w IV hydration+mannitol flush
    • anaphylaxis, ototoxicity
    • do NOT use aluminum needles/IV sets
  34. Methotrexate
    • folic acid antagonist
    • Adverse: ulcerative stomatitis, bone marrow depression, diarrhea, immunosuppressant
    • Leucovorin to 'rescue' bone marrow, antidote for MTX OD
  35. Doxorubicin
    • VESSICANT
    • red urine
    • adverse: cardiomyopathy, dysrhythmia, CHF
    • Maximum cumulative lifetime dose
    • lipid form allows better penetration
  36. Bleomycin
    • Adverse: pulmonary toxicity
    • Maximum cumulative life dose
    • anaphylatic. give test dose
  37. Vincristine
    • VESSICANT
    • Adverse: neurologic rxn, numbness, nerve pain, parathesia
    • NEVER give intrathecal--Fatal
  38. Paclitaxel
    • Severe allergic rxn
    • pretreat with: dexamethasone, diphenhydramine, cimetidine
  39. Irinotecan
    • VESSICANT
    • genetic differences in metabolism + potential for adverse effects
    • Adverse: severe diarrhea. Tx w/ loperamide
  40. Name the 3 vessicant drugs
    • Vincristin
    • Irinotecan
    • Doxorubicin
  41. Name the 2 drugs that have lifetime maximum doses
    • Doxorubicin
    • Bleomycin
  42. Which drug turns urine red?
    Doxorubicin
  43. What drug treats for severe diarrhea?
    Loperamide
  44. What drug treats severe N/V
    ondansetron
  45. Name the 3 drugs used in supportive cancer treatment
    • Allopurinol
    • Analgesics
    • Antiemetics

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