Respiratory Drugs

Card Set Information

Author:
Snooze
ID:
86490
Filename:
Respiratory Drugs
Updated:
2011-05-18 04:35:37
Tags:
Respiratory Drugs
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Description:
Brands/generics/class of drugs
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  1. Albuterol (5)
    • AccuNeb (nebulizer)
    • ProAir
    • Proventil
    • Ventolin
    • VoSpire ER (tab)

    SABA
  2. Xopenex
    • Levalbuterol
    • SABA
  3. Pirbuterol CFC
    • Maxair (breath-actuated)
    • SABA
  4. Metaproterenol
    • Alupent (IV)
    • SABA
  5. Isuprel
    • Isoproterenol
    • SABA
  6. Brethine
    • Terbutaline (PO/SQ)
    • SABA
  7. Formoterol (2)
    • Foradil (asthma) - DPI
    • Perforomist (COPD) - Nebulizer
    • LABA
  8. Arformoterol
    • Brovana (COPD) - Nebulizer
    • LABA
  9. Serevent
    • Salmeterol
    • LABA
  10. Budesonide/Formoterol
    Symbicort
  11. Fluticasone/Formoterol
    Advair Diskus
  12. Dulera
    Mometasone/Formoterol
  13. QVAR
    • Beclomethasone (MDI)
    • ICS
  14. Budesonide (2)
    • Pulmicort - DPI
    • Pulmicort Respules - Nebulizer
    • ICS
  15. Fluticasone
    • Flovent - MDI
    • Flovent Diskus - DPI
    • ICS
  16. Asmanex
    • Mometasone - DPI
    • ICS
  17. Ciclesonide
    • Alvesco - MDI
    • ICS
  18. Montelukast
    • Singulair
    • Leukotriene receptor antagonist
  19. Accolate
    • Zafirlukast
    • Leukotriene receptor antagonist
  20. Zileuton
    • Zyflo
    • 5-Lipoxygenase inhibitor
  21. Why is Singulair more popular than Accolate or Zyflo? (3)
    • Singulair has qd dosing vs BID/QID
    • Less adverse efx (Accolate, Zyflo increases LFTs)
    • Less DDI
  22. Cromolyn
    • Intal - nebulizer
    • Mast cell stabilizer
  23. Theophylline - Brand name? What is its drug class and its effects?
    • Theo-Dur
    • Methylxanthine
    • Increases cAMP and cGMP --> Bronchodilation
  24. What is the desired therapeutic level of serum Theophylline?
    5-15mcg/ml
  25. Which CYP enzyme primarily metabolizes Theophylline?
    CYP1A2
  26. Omalizumab
    • Xolair
    • Immunomodulator
  27. What is Xolair's MOA? How do you determine the dose? How is it administered and how often?
    • Binds to free Immunoglobulin E (IgE) in serum which prevents mast cell degranulation and release of inflammatory mediators
    • Dosing based on serum IgE levels and body weight
    • SC q2-4wks
  28. What is COPD mainly caused by? (Makes it dfferent than asthma)
    Noxious particles or gases
  29. Which 1 of the 2 COPD conditions contains hypertrophy of goblet cells causing excessive mucus secretion?
    Chronic bronchitis
  30. Ipratropium
    • Atrovent
    • Short-acting anticholinergic
  31. Tiotropium
    • Spiriva
    • Long-acting anticholinergic
  32. What is the MOA of anticholinergics?
    Blocks muscarinic ACh receptors (M1, M2, M3) for bronchodilation
  33. Ipratropium + Albuterol
    Combivent (COPD)
  34. Based on UPLIFT trials, spiriva does not increase risks for stroke, heart attack or death. T/F
    True
  35. Roflumilast
    • Dialresp
    • PDE-4 inhibitor
  36. pH
    7.35-7.45
  37. PO2
    80-100mmHg
  38. SaO2
    95%
  39. PCO2
    35-45mmHg
  40. HCO3
    23-28mEq/L
  41. FDA: Singulair is the only leukotriene modifier associated with behavior/mood changes, suicidal ideation, etc. T/F
    • False
    • ALL LM's have the FDA warning
  42. Which drug should not be administered in nebulizer solution with Ipratropium due to formation of ppt?
    Cromolyn (Intal)
  43. COPD - Inflammation and structural changes increase with dz severity but will reverse upon smoking cessation. T/F
    • False
    • Smoking cessation will only decrease progression

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