CHAPTER 23 ENDOCRYNE SYSTEM DRUGS

Secreted to other endocrine glands.

• Thyroxine- thyroid gland
• Cortisol- adrenal glands
• Estrogen- from ovaries
• Testosterone- Testes

Stimulated adrenal cortex to secrete the main corticosteroid called cotisol.

Addison's disease

Causes: Autoimmune, infection.

Cushing's syndrome

Causes: Pituitary tumor, Cortisol treatment.

• Inflammatory conditions:
• Allergic reactions
• Rheumatoid arthritis- oral injectable
• Skin conditions- Topical
• Asthma- Inhaled
• Organ transplantation to prevent rejection.

• Delayed wound healing
• Increased risk of infection
• Osteoperosis (Bone loss)
• Hyperglycemia and diabetes.
• Mood swings, depression

• Avoid prolonged use
• Discontinue gradually

Reduced activity of the thyroid gland.

Synthetic thyroid compounds are more accurately dosed..

SE's: Tachychardia, palpitations, hypertension.

Hyperthyroidism - Graves disease

Causes: Autoimmune 60's- 70's

Hormone produced in the pancreas

Syndrome of hyperglycemia (elevated blood sugar)

• Cardiovascular disease
• Kidney failure
• Blindness
• Nerve Damage

• Diet
• Medication
• -Insulin for type 1
• -Oral antidiabetic agents for type 2

Destroyed by stomach acids. Must be injecte sub Q.

Classified in 2 ways: Onset Duration of action.

along w diet cchanges. oral changes may control blood sugar w out the need for insulin.

Used mainly in type 2 diabetes.