drugs blk5

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sgustafson
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86647
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drugs blk5
Updated:
2011-05-19 12:55:38
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drugs blk5
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  1. pyridostigmine
    • carbamate AChEI
    • treatment of myasthenia gravis to incr muscle tone
    • muscarinic effects: SLUGD
  2. prednisone
    corticosteriod, immunosuppressant, anti-inflammatory
  3. tubocurarine
    • nondepolarizing neuromuscular blocking agent
    • skeletal muscle relaxant
    • competitive inhibitor of ACh
    • worst for histamine release, vasodilation that can result in hypotension, decreased GI tract tone, motility
  4. atracurium
    • skeletal muscle relaxant, intubation
    • fewer SE compared to tubocurarine
  5. rocuronium
    • short-acting nondepolarizing neuromuscular blocking agent
    • duration of action still longer than succinylcholine
    • very few SE
  6. succinylcholine
    • very short-acting depolarizing skeletal muscle relaxant
    • rapidly hydrolyzed by plasma AChE
  7. muscarinic antagonist anti-parkinsonian agents
    • trihexyphenidyl
    • benztropine
  8. Irreversible MAO-B inhibitors for PD
    • selegiline
    • rasagiline
  9. COMT inhibitor for PD
    entacapone
  10. 5HT 1B/1D receptor agonist
    • antimigraine
    • sumatriptan
  11. antimigraine agent, ergot derivative
    dihydroergotamine
  12. verapamil
    • Ca++ channel blocker
    • cardiovascular conditions
    • off-label treatment of migraine
  13. topiramate
    • anticonvulsant, neuropathic pain med
    • NA+, Ca++, GABA effects
    • SE: weight loss
  14. valproic acid
    • anticonvulsant
    • seizures, mania, migraine prophylaxis
    • may affect GABA, Na+
  15. propranolol for neuro symptoms
    • non-selective beta-blocker
    • migraine prophylaxis
    • off label: essential tremor, EtOH withdrawal, performance anxiety
    • binds to beta-2 receptor on muscle spindle to control tremor
  16. primidone
    • anticonvulsant/antiepileptic
    • raises seizure threshold - increases duration of GABA channel opening, results in Cl- influx, hyperpolarization, inhibition
  17. phenytoin
    • anticonvulsant
    • treatment of partial seizures
    • blocks Na+ channels
  18. carbamazepine
    • anticonvulsant
    • partial seizures, trigeminal neuralgia
    • blocks Na+ channels and inhibits sustained repetitive firing
    • induces its own metabolism; CYP 3A4, 2C
  19. phenobarbitol
    • anticonvulsant, barbituate
    • treatment of seizures; sedative
    • increases open time of GABA channels (diff from benzodiazepines)
    • induces CYP 3A4 and 2C
  20. mech of barbituates v. benzodiazepans
    • barbituate: increase open time of GABA channels
    • benzo: increases frequency of GABA channel opening
  21. oxcarbazepine
    • anticonvulsant
    • monotherapy/adjunctive treatment for partial seizures
    • blocks Na+ channels
  22. lamotrigine
    • anticonvulsant
    • stabilizes membranes by blocking Na+ channels, less release of glu/asp, decreased seizure frequency
  23. levetiracetam
    • anticonvulsant
    • Na+ channels, kainate receptor blocker
    • Prevents hypersynchronization of epileptiform burst firing/propogation of seizure activity
  24. zonisamide
    • anticonvulsant
    • partial seizure treatment
    • no effect on GABA, acts on Na+ and Ca++ channels
  25. tiagabine
    • anticonvulsant
    • adjunctive treatment for partial seizures
    • enhance GABA uptake, availability @ postsynaptic neuron
  26. lorazepram
    • benzodiazepine
    • anxiety disorders
    • IV for status epilepticus
    • GABA-A, hyperpolarization

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