Cytokines and other secreted factors

Card Set Information

Author:
minderly
ID:
86759
Filename:
Cytokines and other secreted factors
Updated:
2011-05-19 15:45:49
Tags:
Immunology MS1
Folders:

Description:
producer cells and actions
Show Answers:

Home > Flashcards > Print Preview

The flashcards below were created by user minderly on FreezingBlue Flashcards. What would you like to do?


  1. IL1: 3 producers, 4 actions
    • producers: macrophages, EC, EP
    • actions: inflammation, fever (via prostaglandins), acute phase proteins (liver), increase Th1

    *IL1b triggers systemic inflammation w/ TNFa, IL6
  2. IL2: aka, 3 producers, 2 actions
    • aka: T cell growth factor
    • producers: Th0, Th1, Tc
    • actions: lymphocyte proliferation, NK cytotoxicity
  3. IL3: aka, 2 producers, 1 action
    • producers: CD4+ T cells, thymic epithelial cells
    • action: synergistic action in early hematopoiesis
  4. IL4: 2 producers, 6 actions
    • producers: Th2, mast cells
    • actions:
    • increase mast cells
    • increase Th2 differentiation
    • B cell activation
    • class switch
    • decrease Th1/macrophages (intracellular and extracellular bacteria)
    • decrease IFN-gamma
    • decrease DC IL12 (which decreases NK and Th1)
  5. IL6: 3 producers, 4 actions
    • producers: T cells, macrophages, endothelial cells
    • actions:
    • T cell and B cell growth/differentiation
    • increase plasma cell
    • acute phase
    • fever
    • *systemic inflammatory response (w/ TNFa, IL1b)
  6. IL10: producers, 5 functions
    • producers: Treg and many others
    • actions:
    • increase B cell MHC class 2
    • decrease Th1
    • decrease cytokine production
    • costimulate mast cell
    • generally immunosuppressant (suppress macrophages)
  7. IL12: 2 producers, 2 actions
    • producers: DCs, macrophages
    • actions: increase NK cells, promote Th1 differentiation
    • ex) infection with toxo
  8. IL17: 1 producer, 1 function
    • Th17 cells
    • inflammation- recruit imune cells to infected tissues
  9. IFN-gamma: 4 producers, 4 functions
    • producers: Th1, NK, CD8+ T cells, Treg
    • actions:
    • macrophage activation
    • increase MHC and FcR on B cells
    • increase IgG1 class switching and secretion
    • decrease IL4 and TH2
  10. TNF-alpha: 3 producers, 4 actions
    • producers: macrophages, NK, T
    • actions: local inflammation, fever, toxic shock, increased EC
    • *triggers systemic inflammatory responses (w/ IL6, IL1beta)
  11. TNF-beta: 2 producers, 2 functions
    • producers: T, B cells
    • action: killing, increase EC
  12. CXCL8
    chemotactic factor, recruits neutrophils, basophils, and T cells to infection tissue

What would you like to do?

Home > Flashcards > Print Preview