CD molecules other cell surface molecules

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Author:
minderly
ID:
86769
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CD molecules other cell surface molecules
Updated:
2011-05-19 16:21:36
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Immunology MS1
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Immunology CD molecule list
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  1. CD1
    • nonclassical antigen presentation of nonprocessed, lipid based molecule to T cells
    • loading occurs during various stages of endosomal trafficking
    • can be self/foreign peptides
  2. CD3
    • gamma, epsilon, delta, zeta
    • expressed starting on DN T cells
    • required for signal 1 of T cells
    • analogous to T cell CD79 signal transduction
  3. CD4
    • Class II MHC restricted T cells
    • targeted by HIV
  4. CD8
    Class 1 MHC restricted T cells
  5. VLA5, LFA1
    • lymphocyte homing receptors to site of inflammation
    • addressin molecules: VCAM1, ICAM1 (CD54)
  6. LFA1 (CD11, CD18)
    • tight binding to ICAM-1 (CD54) for adhesion
    • expressed on leukocytes
  7. CD54 (ICAM1)
    • expressed on T cell and APCs
    • binds to LFA (CD11, CD18)
    • flu viruses also bind to nasopharynx ICAM1
  8. L-selectin
    • target naive T cell to 2ndary lymphoid tissues
    • binds to CD34 or GlyCAM1 on HEV or MAdCAM1 on mucosal endothelium
    • initiates lymphocyte rolling and LFA activation
  9. MAdCAM1
    • expressed on mucosal endothelium
    • allows targeting of naive T cell by binding L-selectin
  10. CCR7
    • chemokine receptor on naive T cells
    • interacts with CCL21 on HEV to activate LFA1
    • similar function as L-selectin, CXCR4
  11. CCL21
    HEV surface molecule that interacts with CCR7 to upregulate LFA1 expression on lymphocytes so it can adhere tightly to ICAM and initiate diapedesis
  12. CD45RA, CD45RO
    • naive T cells have CD45RA
    • effector T cells have CD45RO--> lose L-selectin, gain more VLA4 --> bind to VCAM1 and ICAM1 on target tissue endothelium
  13. CCR9, alpha4:beta7 integrin homing receptor
    • chemokine receptor on T cells that are activated in mucosal immune system
    • allows permenant homing to mucosal immune system
  14. CLA
    • expressed by skin homing T cells
    • interacts with E-selectin on cutaneous endothelium
  15. CCL17
    • cutaneous endothelial chemokine
    • allows skin homing T cell targeting via CCR4 binding
  16. CCR4
    • expressed on skin homing T cells
    • interacts with CCL17 (endothelial chemokine)
    • strengthens the CLA to E-selectin bond
  17. CCL27
    • keratinocyte chemokine
    • allows targeting of skin homing T cell via interaction with CCR10
  18. CCR10
    • expressed on skin homing T cells
    • binds to CCL27 on keratinocyte
  19. CD19, CD20, CD21
    • B cell coreceptors that amplify BCR signal
    • complexes with CD81 on APC and T cells
  20. CD22
    • B cell surface molecule
    • APC's CD32 binding downregulate B cell signal
  21. CD32 (FcγRII)
    • expressed by macrophages, granulocytes, platelets
    • inhibits B cell activation via BCR pathway
  22. CD25
    • aka IL2 receptor
    • autocrine growth signal released by T cell following signal 1 + 2
  23. CD40
    • signal 2 for B cells
    • also expressed on APCs
    • binds CD4L (CD154) from T cells
  24. CD79αβ
    • aka Igαβ
    • expressed on mature B cells
    • signal transduction by B cell antigen receptor complex
  25. CD80, CD86
    • aka B7.1, B7.2
    • B cell B7s costimulate T cells via CD28
    • APC B7s inhibit activated T cells via CD152
  26. CD28
    • expressed on most CD4 and CD8 T cells
    • activated by B cell CD80/CD86 (B7.1, B7.2) signals
  27. CD152
    • expressed on activated T cells
    • binding to APC CD80 (B7.1/B7.2) inhibits T cell activity
  28. TLR4
    activated by gram -ve bacteria LPS
  29. TLR2
    activated by gram +ve bacteria lipoproteins, DAG
  30. PRRs
    pattern recognition receptors: detects PAMPs
  31. PAMPs
    pathogen associated molecular patterns: are expressed on microbes
  32. MBL
    • mannose binding lectin
    • an example of PRRs that recognize carbohydrates on microbes
  33. RIG1, MDA5
    • PRRs in cytosol of most cells
    • recognize viral dsRNA--> trigger IRF3, IRF7 transcription factor activation --> type 1 interferon production
  34. S1P1
    • allows activated T cells to egress from thymus/LN to periphery
    • S1P1 blockers suppress immunity
  35. TLR3
    targets viral dsRNA
  36. TLR7
    targets viral ssRNA
  37. TLR9
    targets viral DNA
  38. TLR5
    targets bacterial flagellin
  39. CCR5
    expressed by Th1 for after activation
  40. CCR3
    • expressed by Th2 cells after activation
    • targets Th2 to GC so it can activate B cell isotype class switching

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