Immuno-11 T effectors

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Author:
minderly
ID:
86780
Filename:
Immuno-11 T effectors
Updated:
2011-05-19 16:21:10
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Immunology MS1
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  1. Th1 characteristics
    • Develop from CD4+ cells in response to IL12
    • Secrete gamma-IFN, TNF, and express CCR5
    • gamma-IFN functions:
    • activate macrophage phagocytic activity
    • increase MHC expression on other APCs
    • change antigen processing components of proteosome
    • may signal to uninfected cells in the tissue to upregulate antiviral activities
    • important for clearing intracellular bacteria, viruses, parasites
    • examples: mycobacterium tuberculosis, listeria monocytogenes, influenza, T. gondii
  2. 6 cytokines produced by Th1 and their functions
    • IFN-gamma/CD40L: increase phagocytosis
    • Fas-L: kills host cell, releasing bacteria for phagocytosis
    • IL2: T cell growth factor
    • IL3: induce macrophage differentiation in bone marrow
    • TNF-alpha: increase endothelium permeability so cells can enter infected tissue
    • CCL2: case macrophage accumulation at infection site
  3. Th2 characteristics
    • Develop in response to IL4
    • Secrete IL3, IL4, IL5, IL13 and express CCR3
    • CCR3 targets Th2 to GC to find B cells
    • IL4 promote B cell isotype class switching
    • IL5 attract and activate eosinophils
    • enhance IgE release by B cell associated w/ allergies
  4. Th17 characteristics
    • develop in response to IL1, IL6, and TGF-beta
    • secrete IL17, IL21, IL22
    • IL17--> acts on most cells --> release CXCL8 and CXCL2 --> attract neutrophil/macrophages in infection site
    • important for extracellular pathogens in gut
    • hyper IgE syndrom: low Th17 cells, susceptible to chronic fungal/viral infections
  5. Treg characteristics
    • unknown inducing agent
    • Foxp3 is the key transcription factor for their development
    • secretes IL10
    • Function: Suppress T cell activation to self, peripheral tolerance
  6. 5 gamma-IFN functions
    • activate macrophage phagocytic activity
    • increase MHC expression on other APCs
    • change antigen processing components of proteosome
    • may signal to uninfected cells in the tissue to upregulate antiviral activities
    • important for clearing intracellular bacteria, viruses, parasites

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