Drugs for dyslipidaemia

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  1. Precautions of using a statin?
    • severe intercurrent illness - increases risk of myopathy
    • rhabdomyolysis and renal failure
  2. Which statins are hepatically removed?
    atorvastatin, rosuvastatin,
  3. Adverse Effects of statins?
    myalgia, GI symptoms, insomnia,

    myopathy, rhabdomyolysis, hepatitis,
  4. Which statins have the most interactions?
    atorvastatin and simvastatin
  5. Monitoring of statins?
    aminotransferase and CK at baseline
  6. Dose of atorvastyatin?
    10-80mg daily
  7. Dose of pravastatin?
    20-80mg daily

    40mg daily if unstable angina and post MI
  8. Dose of simvastatin?
    10-80mg daily
  9. What effect do fibrates have on the lipid profile?
    decrease TG and increase HDL
  10. Indications for fenofibrate?
    • severe hypertriglyceridaemia
    • dyslipidaemia associated with type two diabetes
  11. Contraindicatiosn for fenofibrate?

    severe renal impairment
  12. Adverse effects of fenofibrate?
    Increased aminotransferase concentrations, gi disturbances, dyspepsia, photosensitivity, myopathy

    pancreatitis, VTE, rash
  13. Dose of fenofibrate?
    • 145mg daily
    • reduce in renal impairment
  14. Counselling of fenofibrate?
    See doc if you have brown urine, or any muscle pain, tenderness or weakness.

    Avoid sun exposure, wear hat and sunscreen

    Will need blood tests every 3 months for the first year
  15. Indications of ezetimibe?
    • Hypercholesteraemia
    • In combination with a statin, if a statin isnt effective
  16. Precautions of ezetimibe?
    Treatment with fenofibrate - may increase risk of gall bladder disease
  17. Adverse effects of ezetimibe?
    headache, diarrhoea, myalgia, raised ALT
  18. Dose of ezetimibe?
    10mg daily
  19. Counselling for ezetimibe?
    Tell your doctor if you have any muscle pain, tenderness or weakness.
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Drugs for dyslipidaemia
Drugs for dyslipidaemia
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