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Antihistimine administered after epinephrine in the treatment of anaphylaxis; blocks histimine receptors. When stimulated H1 receptors cause bronchoconstriction and contraction of the gut and H2 receptors produce perpheral vasodilation and secretion of gastric acids.
Mechanism of Action
Diphenhydramine is a potent antihistamine that blocks both histimine receptors (H1 and H2)
Anaphylaxis, allergic reactions, urtcaria, extrapyramidal (EPS) reaction-A response to a drug marked by uncontrolled movements, changes in muscle tone, and abnormal posture.
Benadryl should not be used in the management of lower-respiratory diseases such as asthma.
Hypotension, headache, palpatations, and tachycardia have been known to occur following administration of Benadryl. Sedation, drowsiness, and disturbed coordination are common.
Dosage and Administration
- Standard dose of Benadryl is 25.0-50.0mg
- For antihistimine effects: 12.5-25mg IM followed by 12.5-25mg IV
- Pediatric dose-1mg/kg
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