-
Dash Diet =
- low in Na, fat
- high in K+, fiber, calcium
- lowers SBP 8-14
-
Loop Diuretics: Site of Action
loop of henle
-
Thiazide Diuretics: Site of Action
Proximal distal renal tubule
-
K-Sparing Diuretics / Aldosterone Antagonists: Site of Action
Distal renal tubule & collecting duct
-
Carbonic Anhydrase Inhibitors: Site of Action
Proximal renal tubule
-
Lung Ausc: Long Expiratory Phase
COPD
-
Bronchitis Vs Pneumonia
- bronch: prior URI;
- cough, low fever, clear lungs or ronchi, nl CXR;
- Pneumo: acute cough/fever/tachypnea, CP, WBCs, pulmo infilt on CXR
-
Vaginal D/C & Ph DDx
- candida, BV, trich: itching & d/c
- BV / trich: pH > 4.5, candida lower pH
-
Hypertrophic Cardiomyopathy: Genetics, Prevalence, Dx Test, Exam
- auto dom
- most common sudden death <35 yo;
- dx via echo: asymmetric septal hypertrophy & LV outflow obstruction
- squatting increases venous return & decreases murmur
- standing increases venous pooling & murmur
- SEM at LSB
-
Benign Flow Murmurs ___ with Valsalva
diminish or do not change (HOCM increases)
-
Risk Factors for AOM
- <2 yo
- bottle fed
- prematurity
- smoker in house
- daycare
- Native American
-
Recurrent OM =
3 episodes AOM in 6 mos or 4 in 1 yr
-
Sinusitis Abx Tx
- 1st - amoxil or cefuroxime (ceftin)
- PCN allergy: biaxin, azithro, Bactrim
- 2nd: Aug or levo
-
Int/Ext Hordeolum
- internal: meibomian glands
- ext: zeis
-
Hordeolum Tx
- topical Abx (bacitracin or erythro) if w/ blepharoconjunctivitis
- systemic if preseptal cellulitis (keflex/aug)
-
Ages Of Sinus Devt
- maxillary/ethmoid present at birth
- sphenoid: 2-5 yo
- frontal: 7-8 yo
-
HTN BP Goals (For Nl, CAD, DM)
- Nl: < 140/90
- DM or CKD: < 130/80
-
CAD Risk Factors
- FH
- Male
- Hyperlipid
- DM
- HTN
- Inactivity
- Obese
- Smoking
-
Frequency of Tests for HM
- Pap: F sexually active <65 yo
- mammo: ACS qyr >40, USPSTF 1-2yr >50yo
- DRE/PSA: no screen >75 yo
- FOBT: qyr >50
- colonoscopy q10 yr
-
Anticholinergic Effects: S/S, Causative Meds
- dry mouth
- dry eyes
- mydriasis
- urinary retention
- constipation
- ipratropium, tiotroprium
-
HTN Lifestyle Mods
- wt reduction (BMI 18.5 - 25) (biggest fx on bp)
- dash diet
- Na reduction
- aerobic 30 min
- limit EtOH
-
HTN Med Choices: w/o CE
- stage 1: thiazide, ACE/ARB, BB, CCB
- stage 2: 2 drug combo (usu HCTZ + ACE etc)
-
HTN Med Choices: w/ CE
- thiazide: HF, CVD risk, DM
- ARB: HF/DM
- BB: any but CKD/stroke prevention
- CCB: CVD risk/DM
-
Thrombophlebitis Mgmt
- Local heat & elevation
- bed rest
- NSAID
- ASA
- avoid long standing
- assoc w/ DVT in 20%
-
A-Fib Mgmt
- hemo unstable: cardiovert
- stable: consider rate ctrl (BB/CCB), anticoag, poss cardiovert
-
Venous Thrombosis: 80% Occur In:
deep v. of calf
-
Syncope: Types
- Vasopressor
- orthostatic hypotension
- cardiogenic
-
Intermittent Asthma
- sx < 2/week, noc <2/mo
- FEV1 > 80%
- SABA
-
Cough DDx
URI, allergies, asthma, COPD, CA, GERD
-
-
Hypoglycemia
- glucose <60
- usu 2/2 med use
- poss insulinoma
-
Thyroid Nodule: High Index of Suspicion
- h/o xrt
- young men, firm nodule
- hoarse/v. cord paralysis
- high calcitonin
- cold nodule on uptake scan
- solid lesion on u/s
- punctate calcification
- inc in size w/thyroxine tx
-
Chalazion
inflammatory condition 2/2 for body rxn to sebum from meibomian glands
-
Corneal Abrasion
- severe pain/photophobia
- fluorescein: abrasion stains deeper green
- tx: polymyxin-bacitracin ointment, analgesics
-
Vertigo DDx
- Vestibular: BPPV, meniere, vestibular neuritis, labyrinthitis
- Neuro: migraine, MS, stroke
- CV: syncope, ortho hypotension
-
Glaucoma Dx
abnormal in 2 of 3: optic disk (cup-disk ratio >0.5), visual field, intraocular pressure
-
Laryngitis
- persistence may lead to polyps
- M cat or H flu
- erythromycin
-
Pharyngitis: GABHS
- fever >38C
- cervical LA
- no cough
- tonsillar exudate
-
A Fib Dx Work Up
- 12 ECG
- Echo
- CXR
- Thyroid
- poss Holter or stress test
-
Atypical CP, Palps, Anx D/O, Sympathetic Hyperreactivity; Mild Systolic Click +/- MR; Young F>M
MV prolapse
-
MV Prolapse Mgmt
- Echo to dx
- Reassurance
- BB for palps
- ASA for TIA / CVA risk
- surgery for severe MR
-
Varicose Veins Most Common In:
saphenous veins
-
Inflammation, Induration, Erythema & Tenderness Along Superficial V (Usu Long Saphenous V)
phlebitis
-
DVT Mgmt:
- Heparin/Warfarin
- Thrombolytic tx
- Embolectomy
- IVC filter if anticoags are CI
-
DVT Rfs:
- Virchow’s triad
- PG
- CA
- Limb trauma
- Surgery
-
Mild Persistent Asthma
- sx >2/wk
- noc >2/mo
- FEV1 >80%
- Tx: low dose ICS (rhinocort, flovent, nasonex, nasocort)
-
Syncope: Dx Tests
- ECG
- autonomic: tilt table, carotid massage
- electrophysio
- stress test
-
Moderate Persistent Asthma
- sx daily
- noc >1/week
- FEV1 60-80%
- Tx: low-med ICS, LABA (serevent)
-
Severe Persistent Asthma
- continual sx
- freq noc
- FEV1 <60%
- Tx: HD ICS, LABA, and oral CS
-
Hordeolum
- infxs process in eyelid
- usu staph aureus
-
Vestibular Vertigo DDx: Sx Duration
- BPPV <30 sec
- Ménière min to hrs
- vestib neuronitis days
-
Vestibular Vertigo DDx: Sx Provoked By:
- BPPV specific posn changes
- vestib neuronitis: any changes
- Ménière dz tinnitus/n/v, not provoked by posn change
-
Vertigo Testing
- dix-hallpike: +BPPV rotatory nystagmus
- audiogram: nl BPPV/vestib neuritis, low freq SNHL in Ménière
-
Vertigo Tx
- BPPV: epley; vestib neuritis meclizine/valium
- Ménière: low salt/ acetazolamide
-
Glaucoma Tx
- pressure to <16
- prostaglandins (latanoprost)
- topical BB or CAI
- laser trabeculoplasty
-
Whipple Triad (Hypoglycemia)
- hypoglycemic sx (tremor, confusion, sweating, nausea, hunger)
- low BS
- sx resolve when glucose is normal
-
Most Aggressive Lung Ca; Not Surgically Treated; Highest Rate Of Mets; Usu Systemic Dz
small cell lung cancer
-
Most Common Type Of Lung Cancer
non-small cell 80%
-
2 Most Common Types Of Non-Small Cell Lung Cancer
squamous, adenocarcinoma
-
Squamous Cell Lung Cancer Is Usually Where In The Lung
central
-
Adenocarcinoma Lung Cancer Is Usually Where In The Lung
peripheral
-
What Are The Most Frequent Symptoms Associated With Advanced Lung Cancer
- Cough
- wt loss
- dyspnea
- chest pain
- hemoptysis
- bone pain
- lymphadenopathy
- hepatomegaly
- clubbing
- hoarseness
- SVC syndrome
-
Initial Imaging Modality For Suspicion Of Lung Cancer
chest x-ray
-
A __ Lesion On Chest X-Ray Is Considered Malignant Until Proven Otherwise
non-calcified
-
Imaging Used To Evaluate For Lung Mets
pet, brain ct, mr
-
Imaging Modality Considered The Standard Of Care In Proper Staging Of Lung Tumors
bronchoscopy
-
Gold Standard For Lymph Node Evaluation With Lung Cancer
cervical mediastinoscopy
-
Heartburn: DDx
- GERD: regurg, dysphagia
- PUD/ gastritis: epigastric pain, n/v, bloating
- Gallstones: colicky RUQ
- Pancreas: severe constant mid-abd
-
PUD: H Pylori Dx Testing
- rapid urease (s/s 90/98)
- if neg, do histo stain
- sero test (stays pos)
- fecal Ag (can use to test of cure)
- urea breath test
-
Fever, High WBC, LLQ Pain; Poss Painless Rectal Bleed
acute diverticular dz
-
Abd Pain Assoc W/Bowel Dysfn, Often Relieved By BM
IBS
-
Biliary Dz: Dx Test
- u/s is definitive for GS
- u/s or HIDA for cholecystitis
- xray/CT for porcelain
- u/s or ERCP for choledocho
-
Common Causes Of Gastritis
NSAIDs, EtOH, stress, portal HTN
-
Diarrhea
- >3/day or 200 mL
- osmotic vs secretory
- dx: fecal WBC, occult blood, flex sig/bx, upper GI
-
BPH Sxs
- Obstructive: hesitancy, dec force of stream, incomplete voiding, straining, dribbling
- irritative: urgency, freq, nocturia
-
Ed
- 50% of 40-70 yo
- usually organic (vs psych)
- poss CV/DM/ meds
-
Cystitis: DDx
- Women: vulvovaginitis, PID
- Men: urethritis, prostatitis
- bladder CA, voiding dysfn
-
Epididymitis: Men <40 Yo
STI: urethritis, CT or NG
-
Urethritis
- dysuria, pruritus, d/c
- NG or NGU (CT, myco genitalium, ureaplasma)
- ceft/doxy or zithro
-
Vaginitis DDx
- candida (azoles), trich/BV (pH >4.5; flagyl)
- genital warts (podophyllum/ trichloroacetic acid)
-
Breast Mass
fibrocystic (pain, size fluctuation, multiple/bilateral masses);
-
Amenorrhea: Physio
- low/nl FSH: HPA tumor, cushing syn, hypothyroid, high testost, uterine malform
- high FSH: ovar, Turner, autoimmune
- high LH: pseudoherm
-
Incontinence: DRIP
- drugs/delirium
- restricted mobility, retention
- infxn/inflam/impaction
- polyuria
-
Urolithiasis Rfs
- prior stones, FH, low Ca/fluid intake, high oxalate/pro/Na intake, RYGB
- gout, DM, obesity
-
Dysmenorrhea: Tx
- heat, thiamine
- NSAIDs, celebrex
- OCPs
-
Prostatitis
- acute bac: E coli/pseudomonas/ enterococci
- pain, fever, irritative voiding sx
- chronic tx: cipro/septra x1-3 mo
-
CIN1 =
- Cervical intraepithelial neoplasia 1
- low grade lesion, mild dysplasia in lower 3rd of epithelium
- LSIL
-
-
Contraceptive Methods: Most Vs Least Effective
- Most: IUD, implants, sterilization
- Least: diaphragms, condoms, withdrawal/rhythm
-
Shoulder Pain DDx
- rotator cuff
- subacromial bursitis (pain/TTP)
- humerus fx
- biceps tendonitis (groove TTP)
- GH OA
- SLAP tear (no weakness)
-
LBP: Most Common Site Of Disk Herniation
L5-S1 (also L4-L5)
-
Knee Pain DDx
- OA
- Effusion
- pop cyst
- bursitis
- ACL/coll lig
- meniscus tear
- PFPS
- ITB
- stress fx
-
Plantar Fasciitis
- pain worst 1st few steps in AM
- tx: restrict prolonged standing; arch supports
-
Carpal Tunnel Syndrome Dx
- clinical dx
- pain / paresthesia in median n. dist: digits 1-3 & radial half of 4th
- sxs worse at night
-
Hip Pain DDx
- hip dysplasia
- nerve entrapment
- ankyl spondylosis
- RA
- lumbar disk pathology
-
Tests for Suspected (Knee & Hip) OA
- ES
- RF
- synovial fluid analysis
- imaging
-
Fibromyalgia
- F > M 20-50 yo
- neg inflam sxs/labs
- fatigue, HA, numbness
- TCAs, Flexeril, SNRI
-
Peripheral Neuropathy: Axonal Vs Demyelinating
axonal: normal conduction velocity, denervation on EMG; demyelinating: slow velocity, no EMG denervation
-
Tension Type HA
- mild-mod intensity, bilateral, nonthrobbing HA w/o other assoc features
- infreq < 1/mo
- Freq 1-14 days/mo
- chronic > 15 days/mo
- NSAIDs & TCAs
-
MS Testing
MRI, VER, BAER, SSEP, CSF oligoclonal banding, spinal fluid IgG
-
Sudden Onset Of LMN D/O, Asym Facial Paresis, Often Hyperacusis & Impaired Taste
Bell palsy (prev: 30/100K)
-
Contralateral Hemiplegia, Hemisensory Loss, & Homonymous Hemianopia (& Global Aphasia If Dominant Hemisphere Is Affected) =
MCA stroke
-
Essential Tremor
Tx often not needed; propranolol
-
Ottawa Rules: Knee: Xray Only If:
- >55 yo
- isolated tenderness of patella (with no other bony tenderness)
- tenderness at head of fibula
- inability to flex knee to 90 degrees
- inability to bear wt immediately & in ER
-
Knee Pain DDx
- injury to ACL/PCL
- meniscus
- PF syndrome
- Bursitis
- OSD
- ITB
- baker cyst
- OA
- RA
-
GERD: Pathophys, S/S
- low LES/high intra abd pressure
- burning epigastric pain, recurs despite food
- cough, hoarse, dysphagia
-
Barrett Esophagus Physio
low stomach pH changes esoph squamous cells to adenomatous cells
-
GERD: Dx Tests, Tx
- EGD, barium (inc upper GI; sens < EGD), manometry
- tx avoid trigger foods
- H2 or PPI
-
PUD: Tx
triple tx: PPI or H2 + clarithro + amox or flagyl x 7-14 days
-
Diverticular Dz DDx
colon ca, appy, IBD, IBS, ischemic colitis, UTI, PID
-
Ibs DDx
- dietary (lactose)
- celiac dz (wt loss)
- IBD, colon ca (wt loss, anemia)
-
Biliary Dz Rfs
4Fs, Hispanic, rapid wt loss, insulin resistance/ CHO intake, high TG, IBD
-
Biliary Dz Labs
- WBCs in GS/choledocho
- ALT/AST, alk phos, bili
- poss amylase
-
Causes Of Upper GI Bleed
PUD, MW tear, AVM, esophageal varices
-
Diarrhea: Inflam Vs Non-Inflammatory Agents
- inflam: cMV, E histo, EHEC, C diff, SSC
- non-inflam: noro, rota, Giardia, crypto, SA, B cereus, vibrio cholera
-
Diarrhea: Abx For:
- Shigella, cholera, ETEC, C diff
- No Abx for salmo, campy, EHEC, Yersinia
-
BPH Tx
- mild: watchful waiting
- mod-severe: TURP
- med tx (terazosin, doxazosin; finasteride)
-
Cystitis: Tx
- usu E coli / enterococci
- F: FQ (Cipro/oflox), Keflex, macrobid x3days
- complicated gets C&S
-
Oral Rehydration Solution:
3.5 g NaCl, 2.5 g Na HCO3, 1.5 g KCl, 20 g glucose, in 1L water
-
Epididymitis: Men >40 Yo
d/t UTI or prostatitis, usu GNR
-
Epididymitis: S/S
- scrotal pain radiating via spermatic cord to flank
- fever, swelling
- poss prostate TTP
- high WBC
-
Epididymitis: Tx
- STI: ceftriaxone/doxy x10-21 days
- nonSTI: UTI tx (cipro/keflex/septra x21-28 days)
-
Prostatitis: Bac Vs Nonbacterial
- nonbac: no h/o UTI or pos cx
- consider bladder ca in older men: do cytology & cystoscopy
-
Urethritis: DDx
- UTI
- Candida
- noninfxs urethritis (FBO),
- stones
- ReA
- chronic prostatitis
-
Amenorrhea: Dx Tests
LH, FSH, PRL, testost, TSH, FT4, hCG
-
Incontinence: PE
- distended bladder, lg prostate, uterine prolapse, cystocele, rectocele, mass/impaction
- neuro: CVA, spcord dz, cog impairment
-
Urge Incontinence: Causes
usu invol detrusor activity, poss rel to CVA, dementia, PD, spcord injury
-
Incontinence Dx Testing
- ua, PVR (postvoid residual)(usu via cath) >200 mL
- renal labs
-
Most (80%) Kidney Stones Are
- calcium (Ca Ox, Ca PO4)
- others: uric acid, struvite (Mg NH4 PO4)
-
Struvite Stones Form in Pts With
- UTI (proteus / klebs: urease forming)
- staghorn: often struvite
-
Urolithiasis Dx / Tx
- flank pain +/- hematuria
- ID stone
- noncontrast CT/IVP
- 24hr urine, U Ca:Cr ratio
- tx diet to lower Ca/ oxalate
-
CIN 2 =
- high grade lesion
- mod dysplasia, atypical changes in basal 2/3 of epithelium
- HSIL
-
CIN 3
- high grade lesion, severe dysplasia/ ca in situ
- >lower 2/3 of epi plus full thickness lesions
- HSIL
-
CIN & HPV
- HPV 6&11: LSIL, warts
- Benign
- HPV 16 & 18: HSIL, ca
-
Causes of Secondary Dysmenorrhea
endometriosis, adenomyosis, uterine leiomyomata, chronic PID
-
Primary Dysmenorrhea Etiology
frequent/ prolonged uterine contrxns - decrease blood flow to myometrium → ischemia (uterine "angina")
-
OCP Cis
- h/o thrombo / stroke, estro-dependent tumor
- liver dz, PG, CVA or CAD, AUB, smoker if >35 yo
-
Ocps MOA
inhibition of midcycle LH/FSH surge: prevents ovulation
-
Rotator Cuff PE
- RC: pain, less ROM w/overhead supraspinatus (empty can) weak to abd
- Neers: pain w/forward flexion
- Hawkins: pain on int rotation; + drop off test
-
LBP DDx
- cauda equina (urinary probs, fecal incontinence, prog weakness, saddle anesthesia), spondyl (pain improves w/rest)
- tumor, infxn/ inflam (pain doesnt improve)
-
LBP Tests
- xrays if pain >4 wks
- MRI/CT sens > xray for infxn, ca, hern disk, stenosis
- CBC, UA, Ca, PO4, ESR, alk phos
-
LBP: Anemia, ESR
anemia w/MM, high ESR in malig, infxn, CTD
-
Hemarthrosis
usu d/t injury (most common ACL), rapid effusion (2-4 hrs)
-
Most Common Cause Of Knee Pain In Pts <45 Yo =
-
Young Pt W/Ant Knee Pain Worse W/Repetitious Flexion & Without Clear Alternative Cause:
PFPS
-
Local TTP, Pain On Motion And At Rest; Occasional Loss Of Active Movement; Swelling, Erythema, Warmth:
bursitis
-
Most Common Knee Injuries
- medial: anserine bursitis
- MCL (most common lig)
- medial meniscus (most vulnerable)
-
2nd Most Common Knee Pain Site
- anterior: PFPS
- prepatellar bursitis
- OSD
- inflam arthritis
-
Least Common Knee Pain Site
-
Diffuse Anterior Knee Pain W/ Swelling & Inflammatory Change
inflammatory arthritis (RA, gout, pseudogout) or septic arthritis
-
OA S/S
- >50 yo
- AM stiffness <30 min
- Crepitus
- Bony tenderness & enlargement
- No palpable warmth
-
Meniscus Tear Dx Made By:
MRI or diagnostic arthroscopy
-
Osteoporosis RF
- Advanced age
- Previous fx
- Also LT glucocorticoid tx
- Low body wt (< 58 kg [127 lb])
- FH hip fx
- Smoking
- Excess alcohol intake
-
Osteoporosis Epi
- F>M (4:1)
- W&Asian > Hisp > AA
- 4 in 10 WF will fx
-
DEXA Values
- T score: BMD > -1SD below YN = nml
- severe osteo = BMD <-2.5
-
Best Predictor Of Fx Risk
bone density (75-85% of variance in bone strength)
-
DEXA Used For:
PA spine, lateral spine, hip, forearm, total body
-
T-Score: Osteopenia
-1 to -2.5 SD below YN
-
Lachman Test Assesses:
anterior-to-posterior laxity
-
McMurray Test:
- rotate foot outward to test medial meniscus
- inward to test lateral; + is painful click
-
Most Common Causes Of Shoulder Pain In Absence Of Trauma =
RC tendonitis, bursitis, bicipital tendonitis
-
CTS Tests
- +Phalen, +Tinel
- NCS/EMG to r/o neuropathy and as pre-op
-
CTS Tx
- wrist splinting
- glucocorticoid injxn (or oral)
- OT/PT (carpal bone mobiln)
- n. gliding
- NSAIDs
- surgery
-
Most Common Hip Problems
Trochanteric & gluteus medius bursitis, OA, femur fx
-
Lateral Hip Pain That Is Aggravated By Direct Pressure
trochanteric bursitis
-
Meralgia Paresthetica Affects The _____ Nerve
lateral femoral cutaneous nerve
-
Positive Faber Test Suggests:
hip disease, iliopsoas spasm, or sacroiliac disease
-
Hip Pain Exam:
inspect, gait, palpate, Faber, SLR, pulses
-
Hip Dx Tests:
- wt bearing xray
- bone scan if suspect fx/necrosis
- MRI TOC for fx not seen in xray, and necrosis/ infxn/tumor
- u/s for kids effusion
-
Acute Monoarticular Sxs, Consider:
tauma, infxn, crystalline dz (gout/ pseudogout)
-
OA Vs RA
- OA: worse w/motion (PM stiffness), better w/rest
- hands DIP Heberdens
- thumb CMC.
- RA: hand MCP/PIP
- warm tender joint swelling
- AM stiffness
-
OA Tx
- short acting NSAID (motrin/naproxen) x2-4 wks
- inc dose prn
- COX-2 in some pts
- Csteroid injxn
-
Fibromyalgia DDx
RA, SLE, hypothyroid, polymyositis (weakness, not pain), polymyalgia rheum, low PO4
-
Most Common Type Of Diabetic Polyradiculopathy =
high lumbar radiculopathy of L2, L3, L4 roots, causing diabetic amyotrophy
-
Osteonecrosis
- Groin pain (less often thigh / buttock pain) = femoral head dz. Wt-bearing & pain w/motion, possibly rest/night pain
- RF: steroids
- dx: MRI sens > xray/scan
-
Severe Anterolateral Hip Tenderness, Severe Pain W/Wt Bearing, Intolerance To Passive Hip Rotation; Xray Normal (Dx W/MRI) =
occult hip fx (nondisplaced fx of femoral neck)
-
Cluster HA
unilateral, orbital/temporal w/tearing; Tx O2, sumatriptan, prevent w/verapamil
-
HA Prevalence
cluster M>F, parox hemicrania F>M
-
HA: Serious Sxs
- meningits (fever, HA, stiff neck: LP/bld cx)
- SAH (sudden onset: CT); subdural
-
Ms S/S
- 15-50 yo
- optic neuritis
- fatigue
- Lhermitte sx
- Uhthoff's phenomenon
-
MS Tx
- methylprednisolone/ IVIg for acute
- glatiramer & interferon for relapsing- remitting sx
-
Bell Palsy DDx
Lyme dz, tumor, AIDS, sarcoidosis, herpes zoster in geniculate ganglion
-
MCA Stroke: Anterior Main Div Occlusion Vs Posterior
- anterior occlusion: expressive dysphasia
- posterior: receptive/ Wernicke
-
Posterior Cerebral Artery Occlusion Leads To:
thalamic syndrome: contralateral hemisensory deficit, spont pain & hyperpathia
-
Anterior Comm Artery Occlusion Causes:
weakness & cortical sensory loss in contralateral leg, poss arm weakness
-
Ischemic Stroke Tx
ASA, some get thrombolytics (dipyridamole, heparin for cardioembolic)
-
Hemorrhagic Stroke Tx
supportive; poss surg (stroke/AVM); aneurysm clipping/coil embolization
-
Anemia: RBC Production Problem (Vs Destruction Prob) Distinguished By:
- Retic count
- hypoproliferative = retic low (<2); hyper = retic high (>3)
-
Formula: Corrected Retic
% retic x HCT/45% = absolute % retics
-
Causes Of Fe Def Anemia
- Dec’d intake/ Poor diet
- dec’d absorption
- Inc’d loss (GI bleed, menorrhagia,neoplasm)
- Inc’d reqs (PG, lactation)
-
Anemia Of Chronic Dz
- Mostly normal labs (poss microcytic)
- low erythropoietin
- tx underlying dz & coexisting defs; epo?
-
S/S = Glossitis, Periph Neuropathy (Stocking-Glove Paresthesias); MCV 110-140; Low Retic, Hyperseg Pmns, High Methylmalonic A.
B12 def
-
Folic Acid Def Findings
- Malnourished
- glossitis, cheilitis
- NO neuro S/S
- RBC folate <150 ng/mL
-
Triad: Anemia, Splenomegaly And Jaundice
Hereditary spherocytosis
-
Microcytic Anemia: DDX
TICS: thal, iron def, chronic inflammation, sideroblastic
-
Macrocytic Anemia
folate or B12 deficiency
-
Normoocytic Anemia
anemia of chronic dz?
-
Tx For Beta Thal Major
Txn, splenectomy, Fe chelation; allogeneic BM trans to cure
-
Beefy Red Patches/Plaques With Satellite Lesions =
Candidiasis
-
Lower Respiratory Tract Starts Below What Anatomic Structure
vocal chords
-
Diagnosed By New Infiltrate On Exam Or X-Ray
pneumonia
-
No. 1 Cause Of Death From Infectious Disease In The US Is From
pneumonia
-
Hospital Aquired Pneumonia Is Defined As Symptom Onset >___ Hours After Hospital Admission
48
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Most Common Bacterium Associated With Pneumonia World Wide
Streptococcus pneumoniae
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Pneumococcus Colonizes ____% of Healthy Adults
5 to 10
-
May Have Associated Non-Respiratory Syndromes (CNS, Immune Hemolytic Anemia)
Mycoplasma pneumoniae
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‘Discovered’ In 1976; Found In Aquatic Environments
Legionella pneumophilia
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50% Of 20 Yo Have Serologic Evidence Of Past Infxn; Assoc W/ Chronic Inflammatory Dz (Atherosclerosis)
Chlamydia pneumonia
-
May Cause Necrotizing Infiltrates Or Pneumatoceles
- GN org or Staph pneumonia
- aspiration pneumonia
-
Inhalation Of Oropharyngeal Or Gastric Contents (Volume-Dependent)
aspiration pneumonia
-
RF For Infxn With Drug Resistant Pneumococci
recent beta lactam tx (within the past 3 months); >65 yo
-
RF For GN Pneumonia Infxn
residence in a nursing home
-
RF For Enteric GN Pneumonia Infection
underlying cardiopulmonary dz
-
RF For Pseudomonas Aeruginosa Infxn
- Corticosteroid tx (> 10 mg/d of prednisone)
- Structural lung dz (bronchiectasis)
- Broad-spectrum abx (> 7 d in past month)
-
Respiratory Quinolone
Moxifloxacin, gatifloxacin, levofloxacin, or gemifloxacin
-
Outpatient Therapy For Pneumonia In Otherwise Healthy Patients
- Advanced generation macrolide (azithro or biaxin)
- doxycycline if allergic
-
Outpatient Tx For Pneumonia In Pts W/ Cardiopulmonary Dz And/Or Other Modifying Factors
Anti-pneumococcal FQ: macrolide PLUS b-Lactam (oral cefpodoxime, cefuroxime, high-dose amoxicillin, amox/clavulanate; or parenteral ceftriaxone followed by oral cefpodoxime)
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Rate Of Influenza Has _____ Cf To Previous Decade, Poss D/T Aging Popn And/Or Change In Predominating Viral Strains (H3N2)
doubled
-
Influenza Has An Incubation Period Of ___ Days
1 to 4
-
Fever, Myalgia, Headache, Malaise, Nonproductive Cough, Sore Throat, Rhinitis Are All Symptoms Of
influenza
-
Influenza: Resolution in ___ Days, Though Cough And Malaise Can Persist For Over 2 Weeks
5 to 7
-
Children With Influenza May Present With
otitis media, nausea, vomiting
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Viral Cultures Are Optimal From ______ Specimens And Require Specific Viral Culture Media
nasopharyngeal
-
Only _______ Effective Against Both Influenza A And B
ostelmavir and zanamivir
-
Who Needs Annual Influenza Vaccinations
- 6 mo-18 yo & >50 yo
- LT aspirin tx; PG
- chronic med conditions (pulmo, cardiac, metabolic, renal, neuro, immunodef, hemoglobinopathy)
- nursing home res
-
Radiographic Findings Include Infiltrates In Mid Or Lower Lung Fields, Hilar Adenopathy, Cavitation
tuberculosis
-
Cough, Weight Loss, Fever, Night Sweats, Hemoptysis, Fatigue, Decreased Appetite, Chest Pain Can Be The Clinical Presentation Of _____
reactivated tuberculosis
-
CXR With Upper Lobe Infiltrates, Particularly The Apical And Posterior Segments, Cavitation Common
reactivated tuberculosis
-
Lower Respiratory Tract Is Normally Sterile If
directly sampled
-
Acceptable Sputum Spec: <__ Squamous Epithelial Cells/Low Power Field
10
-
Macrophages: Activated Phagocytic Cells Common In ____
fungal, acid-fast & some atypical bacterial infections
-
Most Common Cause Of Bacterial Pneumonia (70%)
Streptococcus pneumoniae
-
Lancet Shaped Gram Positive Cocci In Pairs
Streptococcus pneumoniae
-
Culture Is Never Indicated In
chronic bronchitis
-
If You Suspect Atypical Bacteria You Should
notify the lab in advance
-
TB Infection Spread Person To Person Via ____
respiratory droplets in air (cough)
-
Positive PPD Zone Size >= __ Mm If No Risk Factors
15
-
Positive PPD Zone Size >= __ Mm If Co-Morbid RF (DM, CKD, Ca, IVDA, Congregate Setting, Immigrant <5yrs from Endemic Area (Asia, Africa, Latin America), Mycobacteriology Lab Tech, Gastrectomy
10
-
Positive PPD Zone Size >= __ Mm If HIV+, Contact Of TB+ Person, Organ TP/Immunosuppression, Fibrotic CXR, On 15 Mg Prednisone/Day, Or TNF Alpha Inhibitor
5
-
Substance Used For Control In PPD Test
candida albicans antigen
-
The Inability to React To Skin Tests Because Of A Weakened Immune System
anergy
-
More Specific Test For LTBI & Can Help Exclude BCG Or Mycobacterium Not TB Reactions.
Interferon Gamma Release Assay
-
Vaccine Against Tuberculosis
Bacille Calmette-Guérin (BCG)
-
Onset Of Action 5-30 Minutes, With Relief For 4-6 Hours
SABA
-
Beta 2 Agonists Have No Anti-Inflammatory Effects and Therefore
should not be use as the sole therapeutic agent for management of persistent asthma
-
Patients Achieving ____ Consecutive Months of Improved Asthma Control May Be Considered For a Reduction in Inhaled Corticosteroid Dosing
3 to 6
-
Patients With Severe Exacerbation Of Asthma May Require
IV injection of methylprednisolone or oral prednisone
-
Allows For Modest Reductions In Doses Of Beta2 Agonists And Corticosteroids
leukotriene antagonists
-
Pretreatment With ____ Blocks Allergen And Exercise Induced Bronchoconstriction
cromolyn
-
Blocks Vagally Mediated Contraction Of Airway Smooth Muscle And Mucus Secretion
ipratropium
-
Not Traditionally Effective In The Treatment Of Asthma Unless COPD Is Also Present
ipratropium
-
May Be Particularly Useful In Patients with Moderate To Severe Asthma That Are Poorly Controlled With Conventional Therapy
omalizumab
-
The Foundation Of Therapy For COPD
inhaled bronchodilators such as anticholinergic agents
-
Liver Function Monitoring Is Essential For
leukotriene modifiers
-
Inhaled Bronchodilators That Have A Duration Of Bronchodilation Of At Least 12 Hours After A Single Dose
LABA
-
The Preferred ICS For Pregnancy
budesonide
-
Preferred Step 1 Treatment For Patients 12 And Up
SABA PRN
-
Preferred Step 2 Treatment For Patients 12 And Up
low dose ICS
-
Preferred Step 3 Treatment For Patients 12 And Up
low dose ICS plus LABA or medium dose ICS
-
Preferred Step 4 Treatment For Patients 12 And Up
medium dose ICS plus LABA
-
Preferred Step 5 Treatment For Patients 12 And Up
high dose ICS plus LABA and consider omalizumab for patients with allergies
-
Preferred Step 6 Treatment For Patients 12 And Up
high dose ICS plus LABA plus oral corticosteroids, and consider omalizumab for patients with allergies
-
Regular Tx With _____ Does Not Modify Long Term Decline In FEV1, But Reduces Frequency Of Exacerbations In COPD Pts W/ FEV1 Of <50%, And Repeated Exacerbations
inhaled glucocorticosteroids
-
Long Term Treatment With ______ Is Not Recommended In Patients With COPD
oral glucocorticosteroids
-
Reduces Serious Illness And Death In COPD Patients By 50%
influenza vaccine
-
Initiate Oxygen Therapy For Very Severe COPD If Paox Is At Or Below ___ Kpa Or Sao2 Is At Or Below __%
7.3, 88
-
Antibiotics Should Be Given To COPD Patients With:
increased dyspnea, increased sputum volume, increased sputum purulence, or who require mechanical ventilation
-
Carry A Black Box Warning For Asthma (Especially When Used As Monotherapy)
LABA
-
Leukotriene Modifier
Singulair
-
Approved For Allergic Rhinitis
Singulair
-
Effective For Seasonal Asthma And For Prevention Of Exercise Induced Bronchospasm
mast cell stabilizers
-
Effective For Seasonal Asthma And For Prevention Of Exercise Induced Bronchospasm
Cromolyn sodium and nedocromil
-
Anticholinergic For COPD
tiotropium (spiriva)
-
Anticholinergic For Asthma
Ipratropium (Atrovent)
-
Should Be Done In The AM And Between Noon And 2PM For 2-3 Weeks To Establish Personal Best, Then QD
peak flows
-
Ultimate Goal Of COPD Therapy
prevention
-
Oxygen, Consider Surgery
very severe COPD (stage 4)
-
Inhaled Corticosteroids In COPD
severe (stage 3), and very severe (stage 4)
-
Not Recommended In COPD
expectorants, mucolytics, antitussives, respiratory stimulants
-
Only Therapy To Show Mortality Benefit In COPD
oxygen
-
Goal Of Oxygen Therapy
increase PaO2 to > 60 mmHg
-
Short-Term Cough, Producing Mucoid Sputum, Persistent Cough After 5 Days Of URI, Usually Viral In Etiology
acute bronchitis
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