Norepinephrine (Levophed)

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  1. Class
    Sympathetic agonist
  2. Description
    Naturally occurring catecholamine. Acts on both A and B adrenergic receptors. Alpha effects more profound.
  3. Mechanism of Action

    Norepinephrine is a naturally occurring catecholamine that causes vasoconstriction, cardiac stimulation, and increase blood pressure, myocardial oxygen demand, and coronary blood flow.

  4. Onset of Action
    • Onset: Immediate

    • Peak: <1 min

    • Duration: 1-2 min

    • Half Life: 3 min

  5. Indications
    Used in Hypotension refractory to other sympathomimetics
  6. Contraindications
    Hypotension secondary to Hypovolemia
  7. Precautions
    Can be deactivated by alkaline solutions, Monitor BP, Extravasation can cause tissue necrosis
  8. Side Effects
    Anxiety, headache, hypertension, palpitations
  9. Adult Dose
    • 0.5-1ug/min

    • May go up to 30ug/min if necessary

    • 8mg should be placed in 500ml of D5W giving a concentration of 16ug/ml

  10. Pedi-Dose
  11. Max Dose
  12. Routes of Administration
    IV Drip only
  13. How Supplied
Card Set
Norepinephrine (Levophed)
Norepinephrine (Levophed)
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