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Class
Sympathetic agonist
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Description
Naturally occurring catecholamine. Acts on both A and B adrenergic receptors. Alpha effects more profound.
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Mechanism of Action
Norepinephrine is a naturally occurring catecholamine that causes vasoconstriction, cardiac stimulation, and increase blood pressure, myocardial oxygen demand, and coronary blood flow.
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Onset of Action
Onset: Immediate Peak: <1 min Duration: 1-2 min Half Life: 3 min
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Indications
Used in Hypotension refractory to other sympathomimetics
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Contraindications
Hypotension secondary to Hypovolemia
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Precautions
Can be deactivated by alkaline solutions, Monitor BP, Extravasation can cause tissue necrosis
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Side Effects
Anxiety, headache, hypertension, palpitations
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Pedi-Dose
0.01-0.5ug/kg/min
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Routes of Administration
IV Drip only
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