What are the major glucose carrier protiens and their functons?
Glut1 - A common transport in all mammalian cells, basal glucose uptake. Efficiant transport and capable of working all the time.
Glut2 - Specialized glucose transport in the pancreas and the liver. In the islets of longerhans, beta cells need a glucose sensor. The liver is mainly a fatty acid metabolizer, doesn't take up much glucose but after a meal some glucose may enter.
Glut3 - found in all mammalian tissues, basal glucose uptake
Glut4 - found in muscle and fat cells, it is not an efficiant transporter. Spends most of its time in the cell. When glucose is needed, insulin triggers Glut4 to the cell surface, allowing a large amount of tranport in a short period
Glut5 - found in the intestines