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Where does Ketogenesis occur?
why can't the liver utilize Ketones?
- Only in the Mitochondria and the Liver
- Because it lacks the enzyme Ketoacid Trasferase
What is the rate limiting step of Ketogenesis?
During fasting/ starvation, what two main enzymes are being induced?
- Carnitine palmitoyl transferase I- moves the FA to the mitochondria to be oxidized
- HMG-CoA synthase- Making FA into Ketones for alternate energy source.
During Neonatal period, what intermediates are important for Cerebral Lipid synthesis?
Excessive production of ketone bodies in diabetes patients
Low insulin --> low intracellular sugar. This means that the bodies energy is going to be coming from the breakdown of Fats. The TAG undergo B-Oxidation to become Acety-CoA and in the process generate a ton of NADH. This causes the TCA cycle to slow and makes Acety-CoA find another means of further breakdown. Acetyl-CoA enters Ketongenesis.
What are Eicosanoids and what are they synthesized from?
- They are membrane lipids that are synthesized from the arachidonic acids which is released from the inner leaflet of the membrane.
- They are very unstable and are not transported through the Blood.They travel via diffusion.
arachidonic acid is released from?
The 2nd (A2) position of phosphatidyl inositol
Its produced from Linoleic acid (and essential 18C)
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