shosh: bone tumors

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  1. Osteoma
    • Associated with Gardener's syndrome
    • New bone growth, often on mandible
  2. Osteoblastoma
    • Tumor can lay down new bone matrix
    • Found in vertebral column
  3. Osteoid osteoma
    • Tumor can lay down new bone matrix
    • Lesion is surrounded by osteoblasts
    • Found in proximal tibia and femur
    • Releases prostaglandins that trigger pain (relieved with NSAID)
    • Young men
  4. Giant cell tumor (osteoclastoma)
    • Epipheseal ends of long bones (e.g. knee)
    • Women, age 20-40
    • Double bubble sign on X-ray
    • Spindle-shaped cells with multinucleated giant cells
    • Rb mutation
  5. Osteochondroma
    • Most common benign bone tumor
    • Exostosis
    • Originates from long metaphyses
    • Rare malignant transformation
  6. Enchondroma
    • Cartilaginous neoplasm in intramedullary bone
    • Typically in distal extremities (unlike chondrosarcoma)
    • Can undergo malignant transformation
  7. Osteosarcoma
    • Second most common malignant bone neoplasm (after MM)
    • Often develops in knee (presents with knee pain and swelling)
    • Large anaplastic cells
    • Codman's triangle (from elevation of periosteum) on X-ray
    • Poor prognosis
  8. Ewing's sarcoma
    • Small, PAS+ blue cells
    • Aggressive, but radiosensitive
    • Onion skin appearance
    • 11:22 translocation
  9. Chondrosarcoma
    • Malignant cartilage tumor
    • Appears in men, ages 30-60
    • Usually in pelvic or shoulder girdle
    • May be primary, or may progress from osteochondroma
  10. Osteoblastic lesions
    Prostate mets
  11. Osteoblastic AND osteolytic lesions
    Breast mets
Card Set
shosh: bone tumors
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