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  1. Magnesium Sulfate

    Trade Name
  2. Magnesium Sulfate

  3. Magnesium Sulfate

    Mechanism of Action
    • Reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholinesterase release at the myoneural junction
    • Manages seizures in toxemia of pregnancy Induces uterine relaxation
    • Can cause bronchodilation after beta-agonists and anticholinergics have been used
  4. Magnesium Sulfate

    • Seizures of eclampsia (Toxemia of pregnancy)
    • Torsades de Pointes
    • Hypomagnesemia
    • Bronchospam-Severe Respiratory Distress
    • TCA overdose-induced dysrhythmias
    • Digitalis-induced dysrhythmias
    • Agent for refractory VF and VT
  5. Magnesium Sulfate

    • Heart blocks
    • Renal diseases
  6. Magnesium Sulfate

    Adverse Reactions
    • Respiratory and CNS depression
    • Hypotension
    • Cardiac arrest
    • Asystole
    • Facial flushing
    • Diaphoresis
    • Depressed reflexes
    • Circulatory collapse
  7. Magnesium Sulfate

    Drug Interactions
    • May enhance effects of other CNS depressants
    • Serious changes in overall cardiac function may occur with cardiac glycosides
  8. Magnesium Sulfate

    How Supplied
    2 ml and 20 ml vials of a 50% solution
  9. Magnesium Sulfate

    Dosage and Administration
    • Seizure activity associated with pregnancy: 1-4 grams IV push over 3 minutes
    • For Torsades de Pointes or Refractory VF/VT: 1-2 grams IV push over 1-2 minutes
    • Bronchospasm: 2-4 grams IV push over 5 minutes
  10. Magnesium Sulfate

    Dosage and Administration
    Not recommended
  11. Magnesium Sulfate

    Duration of Action
    • Onset: Immediate
    • Peak effect: variable
    • Duration: 3-4 hours
  12. Magnesium Sulfate

    Special Considerations
    • Pregnancy safety: Recommended that drug not be given in the 2 hours before delivery, if possible
    • IV calcium gluconate or calcium chloride should be available as antagonist if needed
    • The "cure" for toxemia is delivery of the baby
    • Use with caution in patients with renal failure
Card Set
Prehospital Medication Flashcards for Paramedic School - Massachusetts and Rhode Island
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