Reduces striated muscle contractions and blocks peripheral neuromuscular transmission by reducing acetylcholinesterase release at the myoneural junction
Manages seizures in toxemia of pregnancy Induces uterine relaxation
Can cause bronchodilation after beta-agonists and anticholinergics have been used
Magnesium Sulfate
Indications
Seizures of eclampsia (Toxemia of pregnancy)
Torsades de Pointes
Hypomagnesemia
Bronchospam-Severe Respiratory Distress
TCA overdose-induced dysrhythmias
Digitalis-induced dysrhythmias
Agent for refractory VF and VT
Magnesium Sulfate
Contraindications
Heart blocks
Renal diseases
Magnesium Sulfate
Adverse Reactions
Respiratory and CNS depression
Hypotension
Cardiac arrest
Asystole
Facial flushing
Diaphoresis
Depressed reflexes
Circulatory collapse
Magnesium Sulfate
Drug Interactions
May enhance effects of other CNS depressants
Serious changes in overall cardiac function may occur with cardiac glycosides
Magnesium Sulfate
How Supplied
2 ml and 20 ml vials of a 50% solution
Magnesium Sulfate
Dosage and Administration
Adult
Seizure activity associated with pregnancy: 1-4 grams IV push over 3 minutes
For Torsades de Pointes or Refractory VF/VT: 1-2 grams IV push over 1-2 minutes
Bronchospasm: 2-4 grams IV push over 5 minutes
Magnesium Sulfate
Dosage and Administration
Pediatric
Not recommended
Magnesium Sulfate
Duration of Action
Onset: Immediate
Peak effect: variable
Duration: 3-4 hours
Magnesium Sulfate
Special Considerations
Pregnancy safety: Recommended that drug not be given in the 2 hours before delivery, if possible
IV calcium gluconate or calcium chloride should be available as antagonist if needed
The "cure" for toxemia is delivery of the baby
Use with caution in patients with renal failure
Author
papeirce
ID
88539
Card Set
magnesiun_sulfate.txt
Description
Prehospital Medication Flashcards for Paramedic School - Massachusetts and Rhode Island