Drugs

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Anonymous
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88662
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Drugs
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2011-06-01 03:59:19
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drugs
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  1. Cetrizidine
    Anti-Histamine (type I hypersensitivity)
  2. loratidine
    Antihistamine (type I hypersensitivity)
  3. Corticosteroids
    Used in: Asthma, Nephrotic Syndrome, Prenatal babies, Infection, etc
  4. Montelukast and Zafirlukast
    • Leukotriene receptor antagonists
    • anti-inflammatory
  5. Ibuprofen, naproxen, diclofenac, Aspirin
    • NSAIDS
    • Inhibit COX, preventing formation of prostaglandins and thromboxane from arachidonic acid.
    • Stomach: lower prostaglandin levels=>no protection from own acid =>ulcer
    • Fever: inhibit COX =>inhibit PGE2
  6. TNF antagonists
    • Infliximab: monoclonal antibody
    • Etanercept: human TNF fusion protein
    • neutralise inflammatory cytokines that mediate (joint) inflammation
  7. Cytotoxic and Antiproliferative Agents
    • Cyclophosphamide
    • Methotrexate
    • (inhibit transplant rejection)
  8. Calcineurin Inhibitors
    • Cyclosporine
    • Tacrolimus
    • (prevent transplant rejection-prevent NFAT->IL2->T cell response)
  9. Rapamycin
    T cell selective immunosuppression. can combine with tacrolimus
  10. Cytokines
    • IFNa: leukaemia, kaposi sarcoma, chronic hep B and C
    • IFNb: MS
    • IL2: mets, immunocompromised, renal cancer
  11. IgG
    • IV
    • Ab deficiencies, immunomodulatory
  12. Monoclonal Ab
    • Herceptin: use in HER2+ breast cancer.
    • binds to HER receptors and stops cell in cycle
    • Rituximab: against CD20 (B cells). leukaemia
    • Infliximab: against TNFa (Lymphocytes) RA
  13. Beta Lactams
    • penicillin
    • flucloxacillin
    • amoxicillin
  14. cephalosporins
    • cefalexin
    • cefuroxime
    • ceftriaxome
  15. macrolides
    • erythromycin
    • clanthromycin
  16. metrondiazole
    • anaerobes
    • entamoeba histolytic
    • giardina lamblia
  17. tetracycline
    • chronic bronchitis
    • chlamydia
    • mycoplasma
  18. rifampicin
    • mycobacteria
    • meningitis prophylaxis
  19. trimethoprim
    • pneumocystis jirovecii
    • toxoplasmosis
    • UTI
  20. amantadine
    influenza A-resistance develops quickly
  21. nucleoside analogue
    • aciclovir (hsv, vzv, proph against herpes in HIV)
    • gangiclovir (HSV, CMV) bone marrow tox!
    • lamivudine (hep B)
    • ribavarin (RSV, Flu A and B, Paraflu. with PegIFN in hep C
  22. HAART
    • NRTI: zidovuzine (HIV, laminidine
    • Protease i.: ritonavir
    • NNRTI: nevirapine
  23. Neuraminidase I.
    • zanamivir
    • osteltamivir
    • flu
  24. interferons gamma
    chronic hep, HPV warts
  25. Azoles
    • fluconazole
    • clotrimazole
    • miconazole
    • itroconazole(candida, crypto., histoplasma,) p450i.
  26. triazoles
    voriconazole (aspergillus)
  27. terinafine
    dermatophytes
  28. Polyene
    • nystatin (ic fungal infections, not dermatophytes)
    • amphotericin B: candida, dermatophytes
  29. Anti Malarial
    quinene, chloroquine, mefloquine, malarone (against schizont stage)
  30. anti helminths
    • albendazole (gut)
    • wemectin (tissue)
  31. loop diuretics
    • furosemide, bumetanide
    • inhibit NaK2Cl in thick ascending LoH
    • used in: heart failure, acute pulmonary oedema, nephrotic syndrome, renal failure
  32. thiazides
    • bendroflumethiazide, metolazone
    • NaCl symport in early DCT (decreases Ca excr.)
    • hypertensions, cardiac failure
  33. K+ sparing
    • Amiloride, Traimterene
    • Late DCT/CD inhibits ENaC
    • combine with thiazide/loop to maintain K+ balance
  34. Aldosterone Antagonists
    • Sprionolactone
    • i. ENaC, ROMK, NaKATP late DCT, CD
    • Conn's, ascites and odema, cirrhosis, with loops in heart failure, with loop/thiazide to maintain K balance
  35. Carbonic Anhydrase i.
    • Acetazolamide
    • i. CA in PCT
    • Glaucoma
    • !=>met acidosis
  36. Osmotic
    • Mannitol
    • osmotic molecules in nephron.
    • treats cerebral oedema
  37. H Pylori Eradication
    • Erythromycin and Metrondiazole (AB)
    • + Omeprazole (PPI)
  38. H2 antagonists
    • Cimetidine (i/ p450)
    • ranitidine
    • nizatidine
    • suppress acid secretion
  39. PPI
    • omeprazole
    • iansoprazole
    • i. proton pumps. (1-2 hrs)

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