Pancuronium Bromide (Pavulon)

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Author:
RLESLIE
ID:
88696
Filename:
Pancuronium Bromide (Pavulon)
Updated:
2011-06-01 16:18:08
Tags:
Pancuronium Bromide Pavulon
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Description:
Pancuronium Bromide (Pavulon)
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  1. Class
    Non-depolarizing neuromuscular blocking agent
  2. Description
    Pancuronium bromide is a derivative of curare and is used to provide skeletal muscle relaxation to facilitate endotracheal intubation.
  3. Mechanism
    of Action
    Pancuronium bromide competes with acetylcholine for cholinergic receptors sites on the postjuctional membrane. This results in paralysis of muscles fibers innervated by the occupied neuromuscular junction. It does not cause an initial depolarization wave as does Succinylcholine.
  4. Onset
    of Action
    • Onset:30-45 sec

    • Peak:3-5 min

    • Duration:30-60 min

    • Half:Life:2 hours

  5. Indications
    Used to achieve temporary paralysis to facilitate endotracheal intubation when muscle tone, seizures, or laryngospasm prevent it.
  6. Contraindications

    Hypersensitivity to drug.

  7. Precautions

    Should have a skilled person in intubation, emergency resuscitation equipment and drugs present, Paralysis occurs in 3-5 min and lasts for approximately 60 min.

  8. Side
    Effects
    Apnea, Aspiration, Bradycardia, Dyrhythmias, Hypotension, Hypertension, Increased intraocular pressure, Increased ICP, Prolonged Paralysis, Respiratory Depression, Sinus Arrest, Wheezing
  9. Adult
    Dose
    0.04-0.1mg/kg repeats doses of 0.01-0.02 mg/kg intravenously as required every 20-40 minutes.
  10. Pedi-Dose
    0.1 mg/kg
  11. Max Dose
    Administer as needed
  12. Routes of Administration
    IV/IO
  13. How Supplied
    Vials

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