Card Set Information
What are the characteristics of IgG?
Single 4 polypeptide structure
Found in serum and tissue
Half life=21 d
Fx=Opsonizations, complement (not IgG4), crosses placenta
What are the characteristics of IgA?
Basic 4 polypeptide strucutre
2 subclasses=monomer (found in serum) and dimer (found in secretions)
J chain (formed by B cell) connects dimer
Has secretory piece involved in transport
DOES NOT cross placenta
DOES NOT fix complement by
What are the chracteristics of IgM?
2 subclasses=monomer (surface of B cell, serves as BCR for Ag) and pentamer (in circulation)
1st made in response to Ag
Found exclusively in serum
DOESNT cross placenta
Great at complement fixation
Not good at opsonization
What are the characteristics of IgD?
Also found on surface of B cell (acts as a BCR for Ag)
What are the characteristics of IgE?
Attaches to Mast Cell surface
Short half life expect when on MC
Impt in allergic and parasitic rxns