Immunology

Card Set Information

Author:
DrA
ID:
88830
Filename:
Immunology
Updated:
2011-06-02 14:39:28
Tags:
Ig Characteristics
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Description:
Ig
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  1. What are the characteristics of IgG?
    • Most abundant
    • Single 4 polypeptide structure
    • MW 150000
    • 4 subclasses
    • Found in serum and tissue
    • Half life=21 d
    • Fx=Opsonizations, complement (not IgG4), crosses placenta
  2. What are the characteristics of IgA?
    • Secretory Ig
    • Basic 4 polypeptide strucutre
    • MW 160000
    • 2 subclasses=monomer (found in serum) and dimer (found in secretions)
    • J chain (formed by B cell) connects dimer
    • Has secretory piece involved in transport
    • DOES NOT cross placenta
    • DOES NOT fix complement by classical pathway
  3. What are the chracteristics of IgM?
    • 2 subclasses=monomer (surface of B cell, serves as BCR for Ag) and pentamer (in circulation)
    • MW=900000 (Largest Ig)
    • 1st made in response to Ag
    • Found exclusively in serum
    • DOESNT cross placenta
    • Great at complement fixation
    • Not good at opsonization
  4. What are the characteristics of IgD?
    • MW 185000
    • Also found on surface of B cell (acts as a BCR for Ag)
  5. What are the characteristics of IgE?
    • Smallest Ig
    • MW 200000
    • Attaches to Mast Cell surface
    • Short half life expect when on MC
    • Impt in allergic and parasitic rxns

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