Card Set Information
candidal infections of mouth
What species cause candida infections?
Commensal organisms, that are opportunistic pathogens.
Most common C.albicans
Others C.Glabrata, Tropicalis, Krusei.
Theses more common in immunosuppressed and neutropenic pts.
Local predisposing factors?
Poor denture hygiene/OH
Local drugs e.g. steroid inhaler
Xerostomia (drugs, SS, radio, diabetes)
Systemic predisposing factors?
Age -extremes (newborn/elderly)
Drugs - AB, steroids
Types of candida infections, classified as ACUTE and CHRONIC name them:
A. Pseudomembranous candidosis
A. Atrophic candidosis
What does Acute Pseudomembranous candidosis look like?
Soft, friable, creamy white plaque on mucosa
Can be wiped off, leaves an erythematous base
What investigation would you do, what would you find? Acute Pseudomembranous candidosis:
Swab, stained smear will show yeasts, hyphae, leukocytes, debris
Cause of Acute Atrophic Candidosis?
Long term steroid/AB
Pts with HIV
What does Acute Atrophic Candidosis look like?
Patchy red mucosal macules due to candida.
Chronic atrophic candidosis fts?
Denture wearers (upper), ortho appliance - continual wear, ill fit, porosity of MMA harbours species
Erythema of mucosa
Dx of Chronic atrophic candidosis
May need to exclude Diabetes.
Chronic Mucocutaneous candidosis (CMC)?
Group of rare syndromes in which there is persistent mucocutaneous candidosis that responds poorly to topical Tx.
Skin, nails, mucosa
Can be sporadic or have familial assoc.
One type is assoc with autoimmune endocrinopathies
Chronic hyperplastic candidiasis characterised by:
Persistent white lesion, tough adherent plaque
Cannot be scraped off
Can have homogenous and non-homogenous areas, speckled
Chronic hyperplastic candidiasis histopathology?
Chronic intra epi inflammation
Fungal hyphae invading superficial layers of the epi
Malignant change of Chronic hyperplastic candidiasis?
30% get dysplasia.
May become carcinomas
Depends on risk factors, appearance (speckled), degree dysplasia
Chronic hyperplastic candidiasis management?
What other lesions may involve candida species?
Median Rhomboid Glossitis