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  1. Prolongs QT
    Torsades de pointes
    Slows phase 0 of cardiac cells
    Displaces digoxin making digoxin more toxic
    Blocks K, incr effective refractory period
    Quinidine - Class IA
  2. Lupus
    Bad for slow acetylator
    Torsades de pointes
    Agranulocytosis
    Slows/prolongs phase 0 of cardiac cells
    Procainamide - Class IA
  3. Lidocaine -CNS effects
    Mexiletine
    • Class IB
    • Prolnogs phase 0 cardiac cells
  4. Flecainide
    • Class 1C
    • Prolongs phase 0 cardiac cells
  5. Class II antiarrythmias
    • Beta blockers
    • Slows/decr phase IV of pacemakers
    • Decr SA/AV activity
  6. Amiodarone
    Sotalol
    Dofetilide
    ibutilide
    • Class III - K channel blockers
    • Incr effective refractory period
    • Prolongs phase III cardiac cells
  7. Prolongs QT
    • -azoles
    • Sotalol
    • Quinidine
    • Amiodarone
    • Hypocalcemia
  8. Pulmonary toxicity
    • Amiodarone (fibrosis)
    • Bleomycin
    • Mitomycin
  9. Class IV
    • Ca channel blockers
    • Verapamil - can lead to CHF
    • Diltiazem
    • Decr phase 0 and phase 4
  10. Can lead to CHF
    • Verapamil
    • Doxorubicin
  11. Drugs causing torsades
    • K channel blockers (class IA and III)
    • Antipsychotics (thioridazine)
    • TCA
  12. Unclassified antiarrythmia
    Decr SA and AV activity
    Can be antagonized by methylxanthines (theophylline and caffeine)
    Adenosine
  13. Unclassified antiarrythmia
    Treats torsades
    Magnesium
  14. Hydralazine
    • Vasodilator acting thru NO
    • SLE syndrome in slow acetylators
  15. Toxicity of nitroprusside
    • Reflex tachycardia
    • Cyanide toxicity
  16. Drugs causing SLE in slow acetylators
    • Hydralazine
    • Isoniazide
    • Procainamide
  17. Ca channel blockers
    • Verapamil (constipation)
    • Diltiazem
    • -dipines (gingival hyperplasa, reflex tachycardia)
    • Dihydropyridine
  18. P450 inducers
    • Quinidine
    • Barbiturates
    • St Johns Wort
    • Phenytoin
    • Rifampin
    • Griseofulvin
    • Carbamazepine
    • Chronic alcoholism
  19. P450 inhibitors
    • Sulfa
    • Isoniazid
    • Cimetidine
    • Ketoconazole
    • Erythromycin
    • Grapefruit
    • Acute alcohol
  20. Digoxin
    • Inhibits cardiac Na/K ATPase --> more intracell Na
    • Incr contractile force
    • Incr vagal tone
    • Prolongs PR interval
    • Bradycardia
    • Hyperkalemia
    • Not used in A Fib
  21. Wolff Parkinson white syndrome
    • Treat w/ class IA or III
    • Don't use digoxin, beta blocker, Ca channel blocker or adenosine
  22. -dipines
    Ca channel blockers w/ special use for Raynaud's
  23. Carbonic anhydrase inhibitors
    • Acetazolamide
    • Dorzalamide
    • Causes metabolic acidosis --> hyperventilation can be used to treat acute mountain sickness
    • Treats alkalosis and glaucoma
    • Works on PCT
    • Causes renal stones
  24. Hypokalemia
    Hypocalcemia
    Hypouricemia
    Sulfa hypersensitivity
    • Loop diuretics
    • Sulfa hypersensitivity only w/ Furosemide
  25. Side effects:
    sulfa hypersensitivity
    Hypokalemia
    Hypercalcemia
    Hyperlipidemia
    Can be used to treat hypertension, CHF, calcium stones, nephrogenic diabetes insipidus
    • Thiazides
    • Avoid use w/ digoxin. Avoid in diabetic pts
  26. Agents that increase HDL
    • Gemfibrozil
    • Niacin
  27. Side effects of flushing, pruritus, rashes, hepatotoxicity, incr HDL
    Niacin/Vit B3
  28. Side effects of Gemfibrozil
    • Gallstones
    • Myositis
  29. Drug used for weight loss
    Inhibits pancreatic lipase
    Decr TGA breakdown in intestines
    Side effects: steatorrhea, diarrhea, decr absorption of lipid soluable vitamins
    Orlistat

Card Set Information

Author:
 Anonymous
ID:
 89477
Filename:
 pharm
Updated:
2011-06-06 19:52:29
Tags:
pharm
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Description:
pharm comlex
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