Warm Reacting Ag System

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Author:
Anonymous
ID:
89666
Filename:
Warm Reacting Ag System
Updated:
2011-06-07 15:57:17
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Immunohematology
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Description:
Immunohematology Warm Reacting Ag System
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  1. Discover of the Kidd System
    Discovered in pregnant woman in 1951 & 1953 because of HDN.
  2. Clinical Significance of Kidd System
    • IgG Antibody
    • Causes delayed HTRxn and HDN
    • Transfusion reaction sever as well as delayed.
  3. Pacific Islanders have what, Kidd?
    Jk Silent Allele
  4. Kidd Antigen Structure
    • 389 Amino Acids
    • Multipass 10 membrane passes
  5. Kidd Antigen responsible for the transport of what?
    • Urea
    • People with null phenotype do not concentrate urine well.
  6. Jka and Jkb are what dominant?
    Co-Dominant
  7. Kidd has how many genes and where?
    4 Allelic genes on Ch#18
  8. What is the Kidd Null phenotype?
    • Jk
    • Silent Allele
    • Discovered in 1959
  9. JK (a- b+)
    What is genotype?
    And percent in population
    • Jkb+ Jkb+ or Jkb+ Jk
    • Whites: 23
    • Blacks: 8
    • Asians: 27
  10. Inhibitor gene for Kidd
    In (JK)
  11. JK (a+ b-)
    What is genotype?
    and percent in population?
    • Jka+ Jka or Jka+ Jk
    • Whites: 26
    • Blacks: 51
    • Asians: 23
  12. JK (a+b+)
    What is genotype?
    • Jka+ Jkb+
    • Whites: 50
    • Blacks: 41
    • Asians: 49
  13. JK (a-b-)
    What is genotype?
    Percent in population?
    • Jk Jk or In (Jk)
    • Polynesians: 0.9
    • Blacks whites and asians: Extremely Rare
  14. Kidd Antibodies
    • Anti Jka
    • Anti Jkb
    • IgG
    • React best in AHG Phase
    • Complement dependant.
    • Storage Weakens Ag
  15. Anti Jka and Jkb react best in what phase?
    • AHG
    • Complement Dependant
  16. What Kidd Ab is most common?
    What percent lack antigen?
    • Jka
    • 25% of whites negative for Jka
    • 9-10% of blacks negative for Jka
  17. Enzymes do what to Jka and Jkb reaction?
    Enhance
  18. Reminder
    Jka and Jkb BINDS COMPLEMENT
    • Reminder
    • Jka and Jkb BINDS COMPLEMENT

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