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  1. What is Niemann Pick Disease (A-B)?
    • It is a defect in shpingomyelin degradation. Sphingomylinase deficiency
    • If A- neuro degeneration and early death
    • If B- Spleen, Liver and Marrow degradation
  2. What is a Glycolipid?
    • It is a Glycosphingolipid. attached via an o-linkage. Plasma membrane outer leaflet. Cell-Cell interaction
    • Cerebrosides- a type of GSL

    Image Upload
  3. What type of Cerebroside is in Glycocalyx?
  4. What are gangliosides?
    What group is added at the end?
    What is needed to add this group?
    • They are the most common Glycosphingolipids. Have strong negative charge
    • NANA (Sialic acid) always on the terminal positions.
    • CMP is needed to add this group
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  5. How botox works?
    • Has NANA (Sialic Acid) at terminus
    • inhibits Ach release--> blocks muscle contraction
  6. Sulfatides, what are they made of?
    • Strong negative charge
    • it is a sulfated galactocerebroside
    • Image Upload
  7. where is Glycolipids made?
    • in the Golgi
    • addition of glycosyl monomers (last added is 1st removed)
    • all sugars must be in the UDP state
  8. Sphingolipidosi: Types and enzymes affected.
    • Deficiency of specific lysosomal hydrolases
    • Types:
    • Tay-Sachs - Hexosaminidase A (red maculla)
    • Niemann-Pick- Sphingomyelinase
    • Fabrys- (X-linked) alpha galactosidase
    • Gauchers- B-Glucosulceramidase
  9. Where does the assemble of Phospholpids occur?
    The smooth ER
  10. What are the differences in the two groups of Phospholipids?
    • Group 1: Have a glycerol spin
    • Ex: Phosphatidic acid (the simplest one)- inclues Cardiolipin, plasmologens and Platelet activation factor

    Group 2: Phosphorlipids that contain 18 Carbons and Sphingosine instead of glycerol.
  11. What are the 3 origins of Phasphatidic Acid?
    DHAP, Glycerol-3-P, and Diacylglycerol
  12. What is cardiolipin?
    • It is two phosphatidic acids esterfied together.
    • There are 4 FA tails
    • it is in the inner mitochondrial membrane and causes the membrane to be very impermiable
  13. What is Platelet activating factor (PAF)?
    It is a phosphaglyceride that causes platelets to aggragate
  14. What are are two most abundant Phospholipids?
    Phosphatidylethanolamine and phosphatidylcholine
Card Set:
2010-03-03 20:14:28

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