Kawasaki.txt

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Author:
kavinashah
ID:
89817
Filename:
Kawasaki.txt
Updated:
2011-06-08 14:26:37
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kawasaki
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kawasaki
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  1. what kind of disease is Kawasaki?
    small-medium vessel systemic vasculitis
  2. why is Kawasaki's disease an important diagnosis to make?
    as aneurysms of coronary arteries are important complication!
  3. what % of cases are affected by coronary artery aneurysm?
    1/3
  4. what age group goes KD affect?
    • 6 month - 4 year
    • peak 1 year
  5. who is KD more common in?
    • Japanese
    • Asians
  6. what is cause of KD?
    • unknown
    • maybe bacterial toxin acting as superantigen
  7. how is diagnosis of KD made?
    • based on clinical findings
    • need 5 out of 6 of:
    • 1. fever for 5 days or more
    • 2. rash: polymorphous
    • 3. bilateral conjunctival injection (non purulent)
    • 4. Lips: red, dry, cracked, strawberry tongue
    • 5. extremities
    • - red palms and soles
    • - indurative oedema of handset
    • - peeling of skin on hands and feet
    • 6. cervical lymphadenopathy: can be unilateral, non purulent
  8. what is differential diagnosis of KD?
    • measles
    • rubella
    • scarlet fever
    • roseola
    • parvovirus B19
  9. which Ix need to be done in suspected KD?
    • FBC, ESR
    • LFT, U&E
    • Throat swab, ASOT
    • Blood culture, viral titre
    • Echo
    • ECG
  10. why is echo done?
    detect coronary artery aneurysm
  11. what is the most effective Rx of KD? and when?
    • IvIg 2g/kg within first 10 days
    • reduces coronary artery aneurysm
  12. apart from IvIg what else is given and why? and dose?
    • aspirin to reduce thrombosis risk
    • first at high anti-inflammatory dose until fever subsides
    • then low anti-platelet dose

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