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What is the path of individual sperm?
- Seminiferous tubules
- Straight tubules
- Rete testis
- Efferent ductules
- Ductus epididymis
- Vas deferens
- Ejactulatory duct
What are the functions of Sertoli cells?
- Blood-testis barrier
- Maintaining high local androgen level
- Secrete inhibin (feedback loop for FSH)
What is the process of sperm maturation?
- Primary spermatocytes (Meiosis I)
- Secondary spermatocytes (Meiosis II)
- Spermatozoa (non-motile)
Where do sperm gain motility?
What is the function of Leydig cells?
What controls them?
- Testosterone secretion
- Regulated by LH (ICSH)
- Inflammation of the epididymis
- Common cause of infertility
- Usually due to gonorrhea
Accessory sex glands
- Seminal vesicle - secretion high in fructose controlled by testosterone
- Prostate gland
- Bulbourethral glands
Describe mechanism of erection
- Parasympathetic release of ACh
- Causes endothelium to release nitric oxide
- NO promotes increased cGMP
- Promotes smooth muscle relaxation/increased blood flow to corpora cavernosa
What is the mechanism of action of Viagra?
Blocks enzyme that breaks down cGMP
What produces Mullerian inhibiting substance?
Benign prostatic hypertrophy
Nodules in mucosal and submucosal regions
PSA and prostatic cancer
Prostate Specific Antigen - increased levels in blood if cancer present
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