Blood

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Author:
jakeschis
ID:
90625
Filename:
Blood
Updated:
2011-06-14 15:06:11
Tags:
blood histology SFOS
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Description:
SFOS - Blood
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  1. Neutrophils
    • 1. granular cytoplam (multiple types of granules)
    • 2. lobulated (2-4) nuclei

    --phagocytize, form pus
  2. Eosinophils
    • 1. large, pink granules (can see crystalloid body in EM, multishaded granules)
    • 2. lobulated nuclei (2)
  3. Basophil
    Dense, dark, large granules (look grainy on EM)

    mast cells are similar, but their nuclei are round/oval and the cells may be spindle shaped
  4. Monocytes
    • 1. large size
    • 2. acentric, kidney shaped nucleus (notable indentation)
    • 3. lack of specific granules
  5. Lymphocytes
    • 1. small size
    • 2. large acentric nucleus
    • 3. narrow rim of cytoplams
  6. Megakaryocyte
    • 1. nucleus is multilobed and folded on itself
    • 2. "foamy" peripheral cytoplasm
  7. Erythropeitic Series
    • 1. Proerythroblast
    • 2. basophilic erythroblast
    • 3. polychromatic erythroblast
    • 4. orthochromatophilic erythroblast
    • 5. reticulocyte
    • 6. Erythrocyte
  8. Proerythroblast
    • 1. large, spherical nucleus
    • 2. one or two visible nucleoli
    • 3. cytoplasm is mildly basophilic b/c of free ribosomes
  9. Basophilic erythroblast
    • 1. smaller than proerythroblast
    • 2. very basophilic cytoplasm
    • 3. smaller, more heterochromatic nucleus
  10. polychromatic erythroblast
    • 1. last cell capable of mitosis
    • 2. hemoglobin production begins
    • 3. cytoplasm gets gray, or dull lilac
    • 4. smaller than basophilic erythroblast
  11. orthochromatophilic erythroblast
    • 1. small, deeply stained nucleus
    • 2. begins to acquire acidophilia
    • 3. retains slight basophilia

    (normoblast)
  12. Reticulocyte
    • 1. nucleus extruded
    • 2. acidophilic cytoplasm with trace of earlier gray

    what's next? erythrocyte -- acidophilic, smaller, biconcave*
  13. Granulocyte Maturation Steps
    • 1. Myeloblast
    • 2. Promyelocyte
    • 3. ________ myelocyte
    • 4. ________ metamyelocyte
    • 5. ________ stab cell
    • 6. neutro/baso/eosino
  14. Myeloblast
    • 1. huge
    • 2. nucleus is large, euchromatic, w/ 3-5 nucleoli
    • 3. NO granules
    • 4. basophilic cytoplasm
    • 5. might have cytoplasmic blebs on periphery
  15. Promyelocyte
    • 1. nucleus indented
    • 2. nucleoli
    • 3. increased size
    • 4. azurophilic granules
    • 5. condensing chromatin
  16. ________ Myelocyte
    • 1. last cell capable of mitosis
    • 2. elliptical nucleus
  17. ________ metamyelocyte
    nucleus becomes progressively indented and heterochromatic
  18. _________ band/stab cell
    nucleus is elongate and aquires a U shape

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