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T cell suppressant - calcineurin inhibitor - binds to cyclophilin to inhibit calcineurin and ultimately repress T-cell expression of cytokines by down-regulating NFAT. Side effects include renal dysfunction; gingival hyperplasia; & hypertension
T cell suppressant - also called FK506 - calcineurin inhibitor - binds to FKBP12 to inhibit calcineurin and eventually prevent T-cell transcription of cytokines by down-regulating NFAT. Side effects include renal dysfunction; gingival hyperplasia; & hypertension
T cell suppressant - mTOR inhibitor - binds to FKBP12 to inhibit mTOR and prevent activation of p70S6 (an enzyme responsible for DNA synthesis & cell proliferation in CD8+ T cells or B cells)
T cell suppressant - inhibits co-stimulation of T cells. Abatacept is a fusion molecule made up of the constant region of Ig fused to the extracellular domain of CTLA-4 (which binds B7 on T cells)
Antibody reagent - depletes helper T cells - composed of horse- or rabbit-derived antibodies against human T cells
Antibody reagent - depletes helper T cells - mouse anti-human monoclonal antibody directed at the CD3 receptor (a protein on the surface of T cells)
Antibody reagent - blocks cytokine signaling - genetically engineered monoclonal antibody with action against IL-2
Cytotoxic drug - interferes with nucleic acid metabolism - prevents clonal expansion of T and B cells - inhibits IMPH (enzyme necessary for synthesis of GTP - necessary for lymphocytes)
Glucocorticoid - works on multiple levels - promotes formation of IKB (which inactivates different molecules that affect transcription) - affects lymphocyte trafficking; inhibits T cell proliferation; inhibits expression of cytokines; inhibits function of macrophages and lymphocytes
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