Immunosuppressant_Drugs.csv

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Author:
elplute
ID:
90737
Filename:
Immunosuppressant_Drugs.csv
Updated:
2011-06-15 10:51:48
Tags:
immunosuppressants
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Description:
Immunosuppressant drugs
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  1. Cyclosporin A
    T cell suppressant - calcineurin inhibitor - binds to cyclophilin to inhibit calcineurin and ultimately repress T-cell expression of cytokines by down-regulating NFAT. Side effects include renal dysfunction; gingival hyperplasia; & hypertension
  2. Tacrolimus
    T cell suppressant - also called FK506 - calcineurin inhibitor - binds to FKBP12 to inhibit calcineurin and eventually prevent T-cell transcription of cytokines by down-regulating NFAT. Side effects include renal dysfunction; gingival hyperplasia; & hypertension
  3. Sirolimus
    T cell suppressant - mTOR inhibitor - binds to FKBP12 to inhibit mTOR and prevent activation of p70S6 (an enzyme responsible for DNA synthesis & cell proliferation in CD8+ T cells or B cells)
  4. Abatacept
    T cell suppressant - inhibits co-stimulation of T cells. Abatacept is a fusion molecule made up of the constant region of Ig fused to the extracellular domain of CTLA-4 (which binds B7 on T cells)
  5. Anti-thymocyte globulin
    Antibody reagent - depletes helper T cells - composed of horse- or rabbit-derived antibodies against human T cells
  6. Muromonab-C3
    Antibody reagent - depletes helper T cells - mouse anti-human monoclonal antibody directed at the CD3 receptor (a protein on the surface of T cells)
  7. Daclizumab
    Antibody reagent - blocks cytokine signaling - genetically engineered monoclonal antibody with action against IL-2
  8. Mycophenolate mofetil
    Cytotoxic drug - interferes with nucleic acid metabolism - prevents clonal expansion of T and B cells - inhibits IMPH (enzyme necessary for synthesis of GTP - necessary for lymphocytes)
  9. Prednisone
    Glucocorticoid - works on multiple levels - promotes formation of IKB (which inactivates different molecules that affect transcription) - affects lymphocyte trafficking; inhibits T cell proliferation; inhibits expression of cytokines; inhibits function of macrophages and lymphocytes

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