Biochem 32-39

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Author:
Anonymous
ID:
90780
Filename:
Biochem 32-39
Updated:
2011-06-15 17:35:13
Tags:
RNA DNA
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Short Course Chapters
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  1. Watson-Crick
    • 1. 2 antiparallel chains, form right-handed double helix
    • 2. Sugar Phospate outside, bases inside
    • 3. 3.4A bases 10 per turn
    • 4. Diameter is 20A
  2. Supercoiling Advantages
    • First, a supercoiled DNA molecule has a morecompact shape than does its relaxed counterpart.
    • Second, supercoiling may hinderor favor the capacity of the double helix to unwind and thereby affects theinteractions between DNA and other molecules.
  3. Annealing
    Opposite of melting or denaturation, spontaneous reassociation of separated DNA to form double helix
  4. DNA Forms
    • A-DNA: less hydrated, wider and shorter, base pairs are tilted rather than perpendicular, still right handed
    • B-DNA: Watson Crick
    • Z-DNA left handed , phosphoryl groups of backbone ar zigzagged.
  5. Cisplatin
    chemotherpy drug, disrupts DNA structure, prevent access to DNA repair enzymes leading to apoptosis
  6. anticipation
    children of affected parent show symptoms of disease at earlier age than parent

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