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- Binds to penicillin binding
- proteins in periplasmic space
- Act by blocking peptidoglycan
- cross linking
- Blocking of cross linking
- weakens cell wall of the bacteria
- Results in the organism
- bursting (lysing)- organism must be actively growing for bactericidal activity to occur bc you need large segments of weakened cell wall for this to work.
- All beta-lactams are bacteriocidial
- Penicillin- ex oxacillinPenicillin G or
- B (drug w/in class penicillin) this is what we think about when we give
- ex. CephalexinHas broader
- spectrum than penicillin5 different
- Carbapenem- ex imipenemVery broad
- spectrumVery powerful
- Monobactam- ex. AztreonamNot used oftenImpt in
- evolution of microbials
- inhibitors- used in combination with beta-lactams- ex. ClavulanateInhibit beta
- lactamases (cleaves beta lactam ring) by binding to the beta lactamase.
- Extremely large glycopeptide
- molecule Only active against gram positive organisms
- Prevents incorporation of murein monomer into peptidoglycan layer