Pharmacology

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Author:
lazzsant
ID:
91085
Filename:
Pharmacology
Updated:
2011-06-17 20:46:00
Tags:
Neurodegenerative Parm
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Description:
Drugs for Parkinsons, Alzheimers, Multiple Sclerosis
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  1. First line drugs for Parkinsons Disease
    If <65 or advanced stages w/ L-Dopa
    • Dopamine Agonists (Neuroprotective)
    • 1) Ropinerole
    • 2) Pramipexole
    • S/E Low BP, compulsive disorder, nausea, confusion, sleep attacks.
    • 3) Apomorphine
    • Rescue drug/ need trimethobenzide for emesis
    • 4) Rotigotine
    • Transdermal patch/ For restless leg syndrome
    • 3) Bromocriptine
    • 4) Perogolide
    • S/E fibrosis & thick valves
  2. First line drug for Parkinsons Disease
    • L-DOPA w/ Carbidopa
    • MOA: precursor for dopamine, protection from AA decarboxylase in periphery
    • S/E: Nausea, vomiting, postural HTN
    • Fluctuations within 5 years
  3. COMT- inhibitors
    • 1) Tolcapone (periphery & central)
    • 2) entacapone (periphery/ S/E liver issues)
    • MOA: helps wearing off phenomenon
  4. MAO-B Inhibitors
    • Neuroprotective
    • 1) Segeline (low dose)
    • 2) Rasagiline
  5. Glutamate Inhibitor
    • 1) Amantadine
    • For drug induced dyskinesias
    • S/E Not for epilepsy or psychiatric
    • 2) Memantine
    • Blocks from excess glutamate
    • Also for Alzheimers
  6. Cholinesterase Inhibitors
    Alzheimers treatment
    • 1) Doneprezil
    • 2) Tacrine
    • 3) Benzodiazepines
    • MOA: Inc Ach to delay progression
  7. Atypical anti-anxiety Drug
    • 1) Busipirone
    • MOA: 5-HT1 agonist
    • For depression
  8. Atypical Anti-depressants
    • 1) Buproprion
    • MOA: Dopamine- Norepinephrine reuptake inhibitor
  9. Multiple Sclerosis drugs
    • 1) Interferons beta(first Line)
    • binds type 1 interferon receptors & prevents antigen presentation
    • 2) Glatiramer acetate(capoxone)[first line]
    • Inc regulatory T cells and suppress inflammation
    • 3) Glucocorticoids
    • No matrix metalloproteinases
    • Blocks leukocytes and phospholipase
    • 4) Natalizumb
    • Suppress leukocyte into CNS
    • 5) Fingolimod
    • Restricts lymphocytes into lymph nodes
    • No autoreactive cells into CNS

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