BioChem

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  1. Describe the chemical transformation that take splace withing the pyruvate dehydrogenase complex.
    Pyruvate's C4 skeleton loses a C, becoming a C3 (hydroxyethyl) which eventually become Acetyl-CoA. The lose of the C is a irreversable step, except in plants and bacteria via the clyoxylate cycle.
  2. What rxn(s) occur in the pyruvate dehydrogenase complex?
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  3. Describe the allosteric regulation of the pyruvate dehydrogenase complex.
    There are two energy state that allosteric regulation occurs in, high and low.

    In high energy NADH, ATP and acetyl-CoA inhibit the pyruvate dehydrogenase complex, preventing Acetyle-CoA, NADH and ATP formation in the cycle.

    In low energy, pyruvate and ADP stimulate the pyruvate dehydrogenase complex.
Author:
smg71206
ID:
9155
Card Set:
BioChem
Updated:
2010-03-04 22:23:47
Tags:
Pyruvate dehydrogenase complex
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Description:
Carbo. Connections
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