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motile anaerobic spirochete
syphilis
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Firm small painless lesion with punched out appearance with rolled edges
chancre
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Primary syphilis S&Sx
- Mild flu like sx
- Adenopathy
- Chancre
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How soon do chancres form?
10-60 days after an infection
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Maculopapular rash affecting the palms and soles of the feet
sceondary syphilis
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Condyloma lata
- flat broad based papules that coalesce
- secondary syphilis
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When does secondary syphilis occur?
4-8 weeks after appearance of chancre
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Mucocutaneous mucous patches
secondary syphilis
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What is the difference between early latent and late latent?
early: <1 year, late >1 year
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Signs of tertiary syphilis
CV damage, gummas, neurosyphilis
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What labs are connected with tertiary syphilis?
- RPR, VRDL
- CSF: pleocytosis and increased protein
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S/sx of neurosyphilis
- HA, N/V
- Seizures, MS changes
- Argyll Roberston Pupils
- Tabes Dorsalis
- Carcot's joints
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Small or large areas of necrosis that are painless
gummas
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Syphilis tx
- PCN G 2.4 mU x 1 dose
- VRDL titers at 3, 6, 12mo
- Abstinence
- Neurosyphilis: continuous infusion of PCN
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