syphilis

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motile anaerobic spirochete

syphilis
Firm small painless lesion with punched out appearance with rolled edges

chancre
Primary syphilis S&Sx
- Mild flu like sx
- Adenopathy
- Chancre
How soon do chancres form?

10-60 days after an infection
Maculopapular rash affecting the palms and soles of the feet

sceondary syphilis
Condyloma lata
- flat broad based papules that coalesce
- secondary syphilis
When does secondary syphilis occur?

4-8 weeks after appearance of chancre
Mucocutaneous mucous patches

secondary syphilis
What is the difference between early latent and late latent?

early: <1 year, late >1 year
Signs of tertiary syphilis

CV damage, gummas, neurosyphilis
What labs are connected with tertiary syphilis?
- RPR, VRDL
- CSF: pleocytosis and increased protein
S/sx of neurosyphilis
- HA, N/V
- Seizures, MS changes
- Argyll Roberston Pupils
- Tabes Dorsalis
- Carcot's joints
Small or large areas of necrosis that are painless

gummas
Syphilis tx
- PCN G 2.4 mU x 1 dose
- VRDL titers at 3, 6, 12mo
- Abstinence
- Neurosyphilis: continuous infusion of PCN